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Articles Published Processes
7/24/2025 9:11:32 AM | Browse: 7 | Download: 47
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Received |
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2025-03-18 13:30 |
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Peer-Review Started |
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2025-03-21 00:08 |
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To Make the First Decision |
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Return for Revision |
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2025-04-07 12:23 |
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Revised |
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2025-04-15 13:36 |
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Second Decision |
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2025-06-16 02:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-17 07:04 |
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Articles in Press |
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2025-06-17 07:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-17 06:42 |
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Publish the Manuscript Online |
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2025-07-24 09:11 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Young-Ju Lim, Min-Soo Seo, Sangbum Park and Gun Woo Lee |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| 2024 Yeungnam University Grant |
224A480005 |
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| Corresponding Author |
Gun Woo Lee, MD, PhD, Department of Orthopedic Surgery, Yeungnam University College of Medicine, No. 170 Hyunchung-ro, Namgu, Daegu 42415, South Korea. gwlee1871@gmail.com |
| Key Words |
Intervertebral disc; Degeneration; Regeneration; Therapy; Stem cell; Extracellular vesicles; MicroRNA; Secretome |
| Core Tip |
Intervertebral disc degeneration (IDD) has been focused on the condition that is linked to several pathological condition, but no effective treatment has been reported so far. Due to the limitations of mesenchymal stem cell-based trials for IDD regeneration, extracellular vesicle or microRNAs derived from mesenchymal stem cell have been evaluated as the next generation of therapeutic option for IDD. Thus, this review aims to provide a comprehensive overview regarding the IDD including anatomical considerations and therapeutic trials with a particular focus on extracellular vesicles and microRNAs. The authors also discuss the challenges and future directions in translating these innovative therapies into clinical practice. |
| Publish Date |
2025-07-24 09:11 |
| Citation |
<p>Lim YJ, Seo MS, Park S, Lee GW. Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cells. <i>World J Stem Cells</i> 2025; 17(7): 107212</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i7/107212.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i7.107212 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
