| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Retrospective Study |
| Article Title |
Chronic hepatitis B with type 2 diabetes mellitus: Association between glycemic control and liver fibrosis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yan Luo, Rui Li, Jun Kang, Ben-Nan Zhao, Li-Juan Lan, Feng-Jiao Gao, Xiao-Xia Ren, Yan-Feng Zhu and Da-Feng Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Sichuan Province |
2023NSFSC0682 |
|
| Corresponding Author |
Da-Feng Liu, Chief Physician, MD, PhD, The First Ward of Internal Medicine, Public Health Clinical Center of Chengdu, No. 18 Jingjushi Road, Jinjiang District, Chengdu 610066, Sichuan Province, China. ldf312@126.com |
| Key Words |
Glycemic control status; Hypoglycemic agents; Liver fibrosis; Type 2 diabetes mellitus; Chronic hepatitis B |
| Core Tip |
This study found that fasting blood glucose significantly mediated the progression of hepatic fibrosis in patients with both chronic hepatitis B and type 2 diabetes mellitus, via the alanine aminotransferase/aspartate aminotransferase pathway. Albumin and gamma-glutamyl transferase levels varied among groups with differing glycemic status, while fibrinogen, the international normalized ratio, serum ferritin, type III procollagen N-terminal peptide, aspartate aminotransferase, prothrombin time, and thromboplastin activity were associated with glycemic levels. These findings indicate that both hepatic impairment and coagulation dysfunction influence glycemic control, and that stringent glycemic management along with the administration of hypoglycemic agents may lower the risk of fibrosis. |
| Publish Date |
2025-07-15 08:26 |
| Citation |
<p>Luo Y, Li R, Kang J, Zhao BN, Lan LJ, Gao FJ, Ren XX, Zhu YF, Liu DF. Chronic hepatitis B with type 2 diabetes mellitus: Association between glycemic control and liver fibrosis. <i>World J Diabetes</i> 2025; 16(7): 107256</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i7/107256.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i7.107256 |
