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Articles Published Processes
6/4/2025 7:41:49 AM | Browse: 3 | Download: 11
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Received |
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2025-03-20 10:46 |
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Peer-Review Started |
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2025-03-20 10:46 |
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To Make the First Decision |
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Return for Revision |
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2025-04-01 12:51 |
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Revised |
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2025-04-03 10:57 |
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Second Decision |
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2025-05-07 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-07 14:12 |
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Articles in Press |
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2025-05-07 14:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-26 02:00 |
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Publish the Manuscript Online |
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2025-06-04 07:41 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Minireviews |
| Article Title |
Off-label use of treprostinil in adult patients in clinical cases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Christina Mouratidou, Efstathios T Pavlidis, Georgios Katsanos, Serafeim-Chrysovalantis Kotoulas, Georgios Tsoulfas, Eleni Mouloudi, Ioannis A Taitzoglou, Ioannis N Galanis and Theodoros E Pavlidis |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Theodoros E Pavlidis, MD, PhD, Professor, The 2nd Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr |
| Key Words |
Treprostinil; Off-label use; Pulmonary hypertension; Digital ischemia; Chronic limb ischemia; Hepatic ischemia–reperfusion injury |
| Core Tip |
Treprostinil is a synthetic prostacyclin analog with a stable structure that is currently used for the treatment of pulmonary arterial hypertension. By way of vasodilation and the inhibition of platelet aggregation, treprostinil increases the blood supply in pulmonary circulation and reduces the cardiac workload. In addition to its main indication, several positive reports of off-label treprostinil use in the adult population indicate its benefit in other clinical conditions. Hepatic ischemia–reperfusion injury, chronic limb ischemia, digital ischemia and group 3 and 4 pulmonary hypertension are currently under study as possible indications for treprostinil use outside its approved labeling. |
| Publish Date |
2025-06-04 07:41 |
| Citation |
<p>Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Tsoulfas G, Mouloudi E, Taitzoglou IA, Galanis IN, Pavlidis TE. Off-label use of treprostinil in adult patients in clinical cases. <i>World J Clin Cases</i> 2025; 13(23): 107279</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i23/107279.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i23.107279 |
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