Publication Name	World Journal of Cardiology
Manuscript ID	107320
Country	China

Received	2025-03-21 16:50
Peer-Review Started	2025-03-21 16:50
To Make the First Decision
Return for Revision	2025-04-09 12:50
Revised	2025-04-10 18:54
Second Decision	2025-05-07 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-07 09:04
Articles in Press	2025-05-07 09:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-15 02:59
Publish the Manuscript Online	2025-05-23 09:07

ISSN	1949-8462 (online)
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Osteosarcopenia in older adults undergoing transcatheter aortic valve replacement: A narrative review of mortality and frailty implications
Manuscript Source	Invited Manuscript
All Author List	Peng Li and Hui-Ping Zhang
ORCID	Author(s) ORCID Number Peng Li http://orcid.org/0000-0002-9153-2955
Funding Agency and Grant Number	Funding Agency Grant Number National High Level Hospital Clinical Research Funding Project No. BJ-2023-206
Corresponding Author	Hui-Ping Zhang, MD, Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dahua Road, Dongdan Dongcheng District, Beijing 100730, China. huipingzhang73@163.com
Key Words	Osteosarcopenia; Frailty; Mortality; Transcatheter aortic valve replacement; Resistance training; Nutrition
Core Tip	Osteosarcopenia, the co-occurrence of muscle atrophy and bone density loss, is increasingly recognized as a potent marker of frailty in older adults undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. This review synthesizes evidence demonstrating that osteosarcopenia affects 15%-20% of TAVR patients and independently predicts 1-year mortality (P < 0.05). Compared to isolated sarcopenia or osteoporosis, osteosarcopenia correlates with higher risks of post-procedural complications, prolonged hospitalization, and functional decline. Key imaging biomarkers—psoas muscle cross-sectional area (muscle mass) and lumbar trabecular attenuation (bone density)—derived from pre-TAVR computed tomography scans provide objective frailty metrics. Integrating these parameters into risk stratification models (e.g., Society of Thoracic Surgeons Predicted Risk of Mortality) enhances predictive accuracy for adverse outcomes. Clinically, routine osteosarcopenia assessment could guide personalized interventions, such as resistance training and protein/vitamin D supplementation, to mitigate frailty-related risks. Early identification of osteosarcopenia bridges geriatric and cardiology care, offering a pathway to improve survival and quality of life in high-risk TAVR populations.
Publish Date	2025-05-23 09:07
Citation	<p>Li P, Zhang HP. Osteosarcopenia in older adults undergoing transcatheter aortic valve replacement: A narrative review of mortality and frailty implications. <i>World J Cardiol</i> 2025; 17(5): 107320</p>
URL	https://www.wjgnet.com/1949-8462/full/v17/i5/107320.htm
DOI	https://dx.doi.org/10.4330/wjc.v17.i5.107320

Full Article (PDF)	WJC-17-107320-with-cover.pdf
Manuscript File	107320_Auto_Edited_055745.docx
Answering Reviewers	107320-answering-reviewers.pdf
Audio Core Tip	107320-audio.mp3
Conflict-of-Interest Disclosure Form	107320-conflict-of-interest-statement.pdf
Copyright License Agreement	107320-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	107320-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	107320-non-native-speakers.pdf
Peer-review Report	107320-peer-reviews.pdf
Scientific Misconduct Check	107320-scientific-misconduct-check.png
Scientific Editor Work List	107320-scientific-editor-work-list.pdf
CrossCheck Report	107320-crosscheck-report.pdf