Publication Name	World Journal of Experimental Medicine
Manuscript ID	107323
Country	India

Received	2025-03-21 01:16
Peer-Review Started	2025-03-21 05:37
To Make the First Decision
Return for Revision	2025-03-26 03:59
Revised	2025-03-29 07:49
Second Decision	2025-04-21 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-21 09:55
Articles in Press	2025-04-21 09:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-01 03:32
Publish the Manuscript Online	2025-08-12 08:18

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Observational Study
Article Title	Safety and efficacy of autologous bone marrow aspirate concentrate injection for idiopathic male infertility: A comparative study
Manuscript Source	Invited Manuscript
All Author List	Ravi Velamoor Rangarajan, Avinash Gandi Devadas, Dhossaradhan Jayakumar Padmanapan, Naveen Jeyaraman, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman
ORCID	Author(s) ORCID Number Ravi Velamoor Rangarajan http://orcid.org/0009-0006-7303-8474 Avinash Gandi Devadas http://orcid.org/0000-0002-6246-0243 Dhossaradhan Jayakumar Padmanapan http://orcid.org/0009-0007-6223-6640 Naveen Jeyaraman http://orcid.org/0000-0002-4362-3326 Swaminathan Ramasubramanian http://orcid.org/0000-0001-8845-8427 Arulkumar Nallakumarasamy http://orcid.org/0000-0002-2445-2883 Sathish Muthu http://orcid.org/0000-0002-7143-4354 Madhan Jeyaraman http://orcid.org/0000-0002-9045-9493
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, Assistant Professor, PhD, Department of Regenerative Medicine, Mother Cell Regenerative Centre, Vayalur, Tiruchirappalli 620017, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Bone marrow aspirate concentrate; Male infertility; Sperm count; Motility; Regenerative medicine
Core Tip	This trial evaluated the safety and efficacy of autologous bone marrow aspirate concentrate (BMAC) therapy for male infertility in men aged 35–45 with severe oligospermia or azoospermia. Over six months, BMAC therapy showed a significant increase in sperm count and motility compared to pharmacotherapy and lifestyle modifications. These results highlight BMAC's potential as a regenerative medicine option for male infertility, warranting further research for clinical application.
Publish Date	2025-08-12 08:18
Citation	<p>Rangarajan RV, Devadas AG, Padmanapan DJ, Jeyaraman N, Ramasubramanian S, Nallakumarasamy A, Muthu S, Jeyaraman M. Safety and efficacy of autologous bone marrow aspirate concentrate injection for idiopathic male infertility: A comparative study. <i>World J Exp Med</i> 2025; 15(3): 107323</p>
URL	https://www.wjgnet.com/2220-315X/full/v15/i3/107323.htm
DOI	https://dx.doi.org/10.5493/wjem.v15.i3.107323

Full Article (PDF)	WJEM-15-107323-with-cover.pdf
STROBE Statement	107323-STROBE-statement.pdf
Manuscript File	107323_Auto_Edited_080946.docx
Answering Reviewers	107323-answering-reviewers.pdf
Audio Core Tip	107323-audio.opus
Biostatistics Review Certificate	107323-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	107323-conflict-of-interest-statement.pdf
Copyright License Agreement	107323-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	107323-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	107323-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	107323-non-native-speakers.pdf
Peer-review Report	107323-peer-reviews.pdf
Scientific Misconduct Check	107323-scientific-misconduct-check.png
Scientific Editor Work List	107323-scientific-editor-work-list.pdf
CrossCheck Report	107323-crosscheck-report.pdf