Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107341
Country	Pakistan

Received	2025-03-21 16:46
Peer-Review Started	2025-03-21 16:46
To Make the First Decision
Return for Revision	2025-04-25 09:07
Revised	2025-04-27 04:51
Second Decision	2025-06-06 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-06 07:11
Articles in Press	2025-06-06 07:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-09 16:33
Typeset the Manuscript	2025-06-27 07:51
Publish the Manuscript Online	2025-07-14 12:56

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Role of interleukins pathogenesis in cholangiocarcinoma: A literature review
Manuscript Source	Invited Manuscript
All Author List	Saira Rafaqat, Hafsa Hamid, Roha Asif, Muhammad Asif, Maria Tariq, Malaika Saleem and Hijab Abaid
ORCID	Author(s) ORCID Number Saira Rafaqat http://orcid.org/0000-0001-7177-5602 Roha Asif http://orcid.org/0000-0003-1031-9237
Funding Agency and Grant Number
Corresponding Author	Saira Rafaqat, PhD, Department of Zoology, Lahore College for Women University, Jail Rd, Near Wapda Flats, Lahore 54000, Pakistan. saera.rafaqat@gmail.com
Key Words	Cholangiocarcinoma; Intrahepatic cholangiocarcinoma; Interleukins; Pathogenesis
Core Tip	Interleukins (IL) contribute to cholangiocarcinoma (CCA) pathogenesis by promoting chronic inflammation, enhancing tumor cell survival, proliferation, and invasion, and shaping a tumor microenvironment that supports cancer growth and metastasis. ILs, which are a group of cytokines, play a crucial role in mediating the immune response and inflammation. This article concludes that IL-1, IL-4, IL-6, IL-8, IL-10, IL-17, IL-23, IL-25, IL-33 and IL-35 play significant roles in the pathogenesis of CCA. Further research is required to find the association of other ILs such as IL-3, IL-5, IL-7, IL-11 and more in the pathogenesis of CCA.
Publish Date	2025-07-14 12:56
Citation	<p>Rafaqat S, Hamid H, Asif R, Asif M, Tariq M, Saleem M, Abaid H. Role of interleukins pathogenesis in cholangiocarcinoma: A literature review. <i>World J Gastrointest Oncol</i> 2025; 17(7): 107341</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i7/107341.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i7.107341

Full Article (PDF)	WJGO-17-107341-with-cover.pdf
Manuscript File	107341_Auto_Edited_065025.docx
Answering Reviewers	107341-answering-reviewers.pdf
Audio Core Tip	107341-audio.aac
Conflict-of-Interest Disclosure Form	107341-conflict-of-interest-statement.pdf
Copyright License Agreement	107341-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	107341-non-native-speakers.pdf
Peer-review Report	107341-peer-reviews.pdf
Scientific Editor Work List	107341-scientific-editor-work-list.pdf
CrossCheck Report	107341-crosscheck-report.pdf