| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Electroacupuncture ameliorates visceral hypersensitivity and negative emotions by regulating paraventricular hypothalamic nucleus and colonic corticotropin-releasing factor signaling
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian-Gang Xu, Yi Yuan, Hong-Kun Ma, Shun Huang, Shan-Lan Zhu, Tan-Ting Li, Xi-Yang Wang, Guo-Ming Shen and Hao Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Excellent Youth Project of Anhui Universities |
2022AH030065 |
| National Natural Science Foundation of China |
82474224 and 82405244 |
| Anhui Provincial Natural Science Foundation |
2408085MH223 |
| Open projects of Anhui Province Key Laboratory of Meridian Viscera Correlationship |
AHMVC2024002 |
| Research Project of Xin’an Medical and Chinese Medicine Modernization Research Institute |
2023CXMMTCM016 |
| the Anhui Province Scientific Research Planning Project |
2022AH050438 |
|
| Corresponding Author |
Hao Wang, Associate Professor, MD, College of Integrated Chinese and Western Medicine (School of Life Science), Anhui University of Chinese Medicine, No. 350 Longzihu Road, Hefei 230012, Anhui Province, China. haohao19870521@126.com |
| Key Words |
Visceral hypersensitivity; Negative emotions; Paraventricular hypothalamic nucleus; Corticotropin-releasing factor; Mast cell/transient potential receptor vanilloid type 1 pathway; Electroacupuncture |
| Core Tip |
An important feature of functional gastrointestinal disorders (FGIDs) is accompanied with emotional disorders, such as anxiety and depression. Clinically, acupuncture not only improves physical symptoms, but also has an unique psychological effect in treatment of FGIDs. However, the underlying mechanisms remain unclear. Brain-gut crosstalk may mediatepathological process of FGIDs, corticotropin releasing factor (CRF) is an important mediator in brain-gut crosstalk. So our study focused on the CRF of brain-gut, we hypothesized that electroacupuncture improved mood disorders and visceral pain in irritable bowel syndrome, which may be achieved through paraventricular nucleus CRF-colonic CRF-receptor 1 and downstream pathway. |
| Publish Date |
2025-08-08 10:23 |
| Citation |
<p>Xu JG, Yuan Y, Ma HK, Huang S, Zhu SL, Li TT, Wang XY, Shen GM, Wang H. Electroacupuncture ameliorates visceral hypersensitivity and negative emotions by regulating paraventricular hypothalamic nucleus and colonic corticotropin-releasing factor signaling. <i>World J Psychiatry</i> 2025; 15(8): 107342</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i8/107342.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i8.107342 |
