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Articles Published Processes
7/25/2025 12:09:40 PM | Browse: 0 | Download: 0
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Received |
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2025-03-26 03:32 |
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Peer-Review Started |
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2025-04-01 00:08 |
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To Make the First Decision |
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Return for Revision |
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2025-04-11 09:57 |
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Revised |
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2025-04-23 11:32 |
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Second Decision |
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2025-06-10 02:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-10 11:22 |
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Articles in Press |
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2025-06-10 11:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-16 01:01 |
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Publish the Manuscript Online |
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2025-07-25 12:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Liver regeneration after partial hepatectomy: Triggers and mechanisms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bakari Korchilava, Tamar Khachidze, Nino Megrelishvili, Lika Svanadze, Manana Kakabadze, Keti Tsomaia, Memed Jintcharadze and Dimitri Kordzaia |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dimitri Kordzaia, MD, PhD, Professor, Alexandre Natishvili Institute of Morphology, Ivane Javakhishvili Tbilisi State University, Beliashvili Str. 78, Tbilisi 0159, Georgia. dimitri.kordzaia@tsu.ge |
| Key Words |
Partial hepatectomy; Liver regeneration; Portal pressure; Portal flow; Cytokines and growth factors; Molecular pathways; Ductular reaction; Structural remodeling |
| Core Tip |
This review synthesizes key triggers and molecular pathways of Liver regeneration after partial hepatectomy, emphasizing the central role of portal hemodynamics, cytokine signaling, and extracellular matrix remodeling. It highlights underexplored processes such as ductular reaction in granulation tissue, and the role of metabolic regulators like bile acids and glutamine. The paper outlines mechanisms of the termination of liver regenerative and proposes new perspectives for its therapeutic modulation in clinical settings. |
| Publish Date |
2025-07-25 12:09 |
| Citation |
<p>Korchilava B, Khachidze T, Megrelishvili N, Svanadze L, Kakabadze M, Tsomaia K, Jintcharadze M, Kordzaia D. Liver regeneration after partial hepatectomy: Triggers and mechanisms. <i>World J Hepatol</i> 2025; 17(7): 107378</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i7/107378.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i7.107378 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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