| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Application of single-cell sequencing in the study of immune cell infiltration in inflammatory bowel disease and colorectal cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Zheng Zhang, Hui-Min Wang, Zhen-Xi Xu, Wen-Yu Luan, Si-Xiang Lin and Yan-Dong Miao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Province Medical and Health Science and Technology Development Plan Project |
No. 202203030713 |
| Yantai Science and Technology Program |
No. 2024YD005 |
| Science and Technology Program of Yantai Affiliated Hospital of Binzhou Medical University |
No. YTFY2022KYQD06 |
| Yantai Science and Technology Program |
No. 2024YD007 |
| Yantai Science and Technology Program |
No. 2024YD010 |
|
| Corresponding Author |
Yan-Dong Miao, Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The Second Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai 264100, Shandong Province, China. miaoyd_22@bzmc.edu.cn |
| Key Words |
Single-cell sequencing; Colorectal cancer; Inflammatory bowel disease; Immune cell infiltration; Tumor microenvironment |
| Core Tip |
Single-cell sequencing technologies are revolutionizing the understanding of immune cell infiltration in colorectal cancer (CRC) and inflammatory bowel disease (IBD). By providing a granular, cell-level view of immune dynamics in these diseases, single-cell RNA sequencing helps identify specific immune cell subpopulations, their roles in disease progression, and their interactions within the tumor or inflammatory microenvironment. This technology enhances the precision of immune profiling, offering new insights for early detection, prognostic markers, and personalized immunotherapies, which are crucial for advancing treatment strategies in CRC and IBD. However, challenges such as data complexity and spatial resolution limitations remain, and ongoing technological innovations are expected to further refine these capabilities. |
| Publish Date |
2025-06-13 13:39 |
| Citation |
<p>Zhang Z, Wang HM, Xu ZX, Luan WY, Lin SX, Miao YD. Application of single-cell sequencing in the study of immune cell infiltration in inflammatory bowel disease and colorectal cancer. <i>World J Gastrointest Oncol</i> 2025; 17(6): 107382</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i6/107382.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i6.107382 |
