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Articles Published Processes
6/20/2025 7:30:12 AM | Browse: 6 | Download: 33
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Received |
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2025-03-24 07:03 |
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Peer-Review Started |
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2025-03-24 07:03 |
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To Make the First Decision |
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Return for Revision |
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2025-03-28 09:49 |
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Revised |
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2025-04-11 11:36 |
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Second Decision |
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2025-05-13 02:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-13 09:55 |
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Articles in Press |
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2025-05-13 09:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-09 11:53 |
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Publish the Manuscript Online |
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2025-06-20 07:30 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Impact of gut microbiome on atrial fibrillation: Mechanistic insights and future directions in individualized medicine
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ajit Singh Brar, Shree Laya Vemula, Vishnu Yanamaladoddi, Sohail Sodhi, Juniali Hatwal, Aalam Sohal and Akash Batta |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Akash Batta, Associate Professor, Department of Cardiology, Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com |
| Key Words |
Atrial fibrillation; Gut microbiome; Dysbiosis; Inflammation; Short-chain-fatty-acid; Trimethylamine N-oxide; Ferroptosis; Lipopolysaccharides; Microbiome-based therapy; Individualized care |
| Core Tip |
Gut microbiome alteration contributes to the generation of harmful metabolites, loss of gut integrity, and cardiac remodeling. Gut dysbiosis interacts with modifiable risk factors to promote cardiac tissue remodeling. Animal models and clinical studies indicate that microbial composition is associated with arrhythmogenesis, atrial fibrillation (AF) recurrence, and modulates medication response. Integrating microbiome surveillance and gut microbiome modulation therapy into AF management may slow disease progression and reduce the arrhythmia burden. However, clinical trials are needed to establish causality and support the incorporation of gut modulation into clinical care. |
| Publish Date |
2025-06-20 07:30 |
| Citation |
<p>Brar AS, Vemula SL, Yanamaladoddi V, Sodhi S, Hatwal J, Sohal A, Batta A. Impact of gut microbiome on atrial fibrillation: Mechanistic insights and future directions in individualized medicine. <i>World J Cardiol</i> 2025; 17(6): 107386</p> |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i6/107386.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i6.107386 |
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