| ISSN |
1948-9358 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Breaking the diabetes-depression cycle: Exploring shared mechanisms, neuroinflammation, and emerging interventions for metabolic-mood comorbidities
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng Luo, Xian-Mei Yu, Mei-Qi Zeng, Cheng-Zheng Duan, Shi-Yu Xu, Chun-Yan Zhu, Zhi-Gang Zheng, Da Sun, Jian Fang and Dong-Juan He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Quzhou Science and Technology Plan Project funded by the Quzhou Municipal Science and Technology Bureau |
2022K67, 2022K69, and 2024K076 |
|
| Corresponding Author |
Dong-Juan He, Chief Physician, Deputy Director, MD, Department of Endocrinology, The Second People’s Hospital of Quzhou, No. 338 Xin’an Avenue, Qujiang District, Quzhou 324002, Zhejiang Province, China. hedongjuan1247@wmu.edu.cn |
| Key Words |
Anti-inflammatory therapy; Bidirectional relationship; Depression; Gut-brain axis; Gut microbiota; Hypothalamic-pituitary-adrenal axis; Immune inflammation; Integrated management; Metabolic abnormalities; Type 2 diabetes mellitus |
| Core Tip |
Type 2 diabetes mellitus and depression share a bidirectional relationship driven by immune inflammation, gut-brain axis dysfunction, metabolic abnormalities, and neuroendocrine dysregulation. Chronic low-grade inflammation, insulin resistance, gut microbiota imbalance, and overactivation of the hypothalamic-pituitary-adrenal axis contribute to both conditions. Emerging treatments targeting these shared mechanisms include anti-inflammatory therapies, gut microbiota modulation, regulation of the hypothalamic-pituitary-adrenal axis, and metabolic interventions such as glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors. A multidisciplinary, integrative approach is essential for effective management, emphasizing the need for comprehensive metabolic-mental health strategies to improve patient outcomes and quality of life. |
| Publish Date |
2025-07-15 08:26 |
| Citation |
Luo C, Yu XM, Zeng MQ, Duan CZ, Xu SY, Zhu CY, Zheng ZG, Sun D, Fang J, He DJ. Breaking the diabetes-depression cycle: Exploring shared mechanisms, neuroinflammation, and emerging interventions for metabolic-mood comorbidities. World J Diabetes 2025; 16(7): 107406 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i7/107406.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i7.107406 |
