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Articles Published Processes
8/21/2025 8:16:42 AM | Browse: 38 | Download: 47
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Received |
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2025-03-25 06:02 |
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Peer-Review Started |
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2025-03-25 06:02 |
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To Make the First Decision |
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Return for Revision |
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2025-05-12 10:07 |
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Revised |
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2025-05-22 08:51 |
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Second Decision |
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2025-08-01 02:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-01 11:07 |
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Articles in Press |
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2025-08-01 11:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-08-04 01:30 |
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Typeset the Manuscript |
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2025-08-13 08:20 |
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Publish the Manuscript Online |
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2025-08-21 08:16 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Role of hydrogen peroxide preconditioning in mesenchymal stem cell-mediated heart regeneration: Molecular insights
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anum Siraj and Kanwal Haneef |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kanwal Haneef, Assistant Professor, PhD, Dr. Zafar H. Zaidi Center for Proteomics, University of Karachi, University Road, Karachi 75270, Sindh, Pakistan. k.haneef@uok.edu.pk |
| Key Words |
Stem cells; Redox signaling; Hydrogen peroxide; Preconditioning; Heart regeneration; Redox sensitive transcription factors |
| Core Tip |
Hydrogen peroxide (H2O2) preconditioning is reported to increase protective mechanisms in mesenchymal stem cells and enhance their ability to regenerate in damaged hearts. However, its molecular mechanism remains under-explored. This review highlights the studies on the protective biological functions and regulatory mechanisms associated with H2O2 preconditioning in heart regeneration. Moreover, the role of the H2O2-activated redox-sensitive transcription factors and their associated pathways in cell survival, proliferation, migration, paracrine effect, and cardiac differentiation are discussed. The molecular insights provided in this review will possibly help in the development of cardiovascular regenerative therapy. |
| Publish Date |
2025-08-21 08:16 |
| Citation |
<p>Siraj A, Haneef K. Role of hydrogen peroxide preconditioning in mesenchymal stem cell-mediated heart regeneration: Molecular insights. <i>World J Cardiol</i> 2025; 17(8): 107437</p> |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i8/107437.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i8.107437 |
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