| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Intravenous vs intraperitoneal mesenchymal stem cells administration: What is the best route for treating experimental colitis?
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Fabiany da Costa Gonçalves, Natália Schneider, Fernanda Otesbelgue Pinto, Fabíola Schons Meyer, Fernanda Visioli, Bianca Pfaffenseller, Patrícia Luciana da Costa Lopez, Eduardo Pandolfi Passos, Elizabeth Obino Cirne-Lima, Luíse Meurer and Ana Helena Paz |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundo de Incentivo à Pesquisa e Eventos do Hospital de Clínicas de Porto Alegre and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
|
|
| Corresponding Author |
Ana Helena Paz, PhD, Professor of Programa de Pós-Graduação: Ciências em Gastroenterologia e Hepatologia, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre 90035-903, Rio Grande do Sul, Brazil. anahpaz@gmail.com |
| Key Words |
Ulcerative colitis; Dextran sulfate sodium; Inflammatory bowel disease; Mesenchymal stem cell; Cell transplantation; Intravenous injection; Immunomodulation |
| Core Tip |
After receiving appropriate biological signals during injury or tissue inflammation, mesenchymal stem cells (MSCs) can migrate to the affected site and suppress effector T cells to modulate inflammatory responses and tissue regeneration. Currently, little is known regarding the optimal delivery strategy for MSCs for the treatment of ulcerative colitis. To our knowledge, no studies have shown which method of cell transplantation is best for the treatment of colon inflammation. The present study demonstrates that intravenous treatment resulted in reduced colon inflammation and is the best route for cell therapy in ulcerative colitis. |
| Publish Date |
2015-01-06 09:08 |
| Citation |
Gonçalves FC, Schneider N, Pinto FO, Meyer FS, Visioli F, Pfaffenseller B, Lopez PLC, Passos EP, Cirne-Lima EO, Meurer L, Paz AH. Intravenous vs intraperitoneal mesenchymal stem cells administration: What is the best route for treating experimental colitis? World J Gastroenterol 2014; 20(48): 18228-18239 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i48/18228.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i48.18228 |
