| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cells apoptosis through CaMKII-Ca2+ pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Yan Chen, Jing-Yi Wen, Jia-Long Lin, Yan Li, Yi-Zhang Wu, Li-Qin Lou, Yong-Liang Lou, Zhi-Gui Zuo and Xiang Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A) |
|
| Wenzhou Science & Technological Project |
Y20240103 |
|
| Corresponding Author |
Xiang Li, Department of Health Inspection and Quarantine, School of Laboratory Medicine and Life Sciences, Institute of One Health, Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Medical Genetics, Ministry of Education, No. 1 Qiuzhen Road, Wenzhou 325035, Zhejiang Province, China. yhx2008@163.com |
| Key Words |
Deoxycholic acid; Reactive oxygen species; Mitochondrial calcium; Apoptosis; Colorectal cancer |
| Core Tip |
This study reveals that deoxycholic acid (DCA) induces colorectal cancer (CRC) cell apoptosis via CaMKII-Ca2+ signaling. Using DLD-1/SW480 models, DCA elevated mitochondrial calcium and reactive oxygen species (ROS) levels, driving apoptosis. Calcium chelation reversed these effects, confirming calcium-ROS interplay as the core mechanism. The findings highlight disrupted calcium homeostasis and oxidative stress in DCA-associated carcinogenesis, providing new therapeutic targets for CRC intervention. |
| Publish Date |
2025-08-14 05:49 |
| Citation |
<p>Chen JY, Wen JY, Lin JL, Li Y, Wu YZ, Lou LQ, Lou YL, Zuo ZG, Li X. Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cells apoptosis through CaMKII-Ca2+ pathway. <i>World J Gastrointest Oncol</i> 2025; 17(8): 107453</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i8/107453.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i8.107453 |
