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Articles Published Processes
8/27/2025 9:21:10 AM | Browse: 66 | Download: 153
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Received |
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2025-03-31 04:09 |
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Peer-Review Started |
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2025-03-31 04:09 |
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To Make the First Decision |
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Return for Revision |
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2025-04-11 00:51 |
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Revised |
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2025-05-09 14:26 |
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Second Decision |
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2025-07-16 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-16 10:26 |
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Articles in Press |
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2025-07-16 10:26 |
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Publication Fee Transferred |
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2025-05-17 01:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-15 03:05 |
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Publish the Manuscript Online |
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2025-08-27 09:21 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatitis B virus rtCYE/rtCYEI mutations may contribute limited tenofovir resistance: Analysis of a large sample of Chinese patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lan-Lan Si, Zhen-Ping Fan, Wen-Hui Liu, Rong-Juan Chen, Xue-Yuan Chen, Dong Ji, Le Li, Chun Chen, Hao Liao, Jun Wang, Dong-Ping Xu, Jun Zhao and Yan Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yan Liu, PhD, Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, No. 100, Xisihuan Middle Road, Beijing 100039, China. liuyan5360@163.com |
| Key Words |
Hepatitis B virus; Mutation; Tenofovir; Drug resistance; Anti-HBV agents; Hepatitis B virus genotype; Replication capacity |
| Core Tip |
Whether rtS106C+H126Y+D134E/rtS106C+H126Y+D134E+L269I (rtCYE/rtCYEI) mutations in the reverse-transcriptase region of hepatitis B virus (HBV) are associated with tenofovir resistance is controversial. The present study investigated many nucleoside/nucleotide analogue (NA)-treated Chinese patients, focusing on the relationship between rtCYE/rtCYEI mutations and tenofovir resistance. We confirmed that rtCYE/rtCYEI mutations were rare (0.042%) in NAs-treated chronic HBV-infected patients and could appear in tenofovir treatment-naïve patients and remain sensitive to tenofovir. The effect of rtCYE/rtCYEI mutations on tenofovir susceptibility was limited. This study extends the current knowledge related to HBV resistance, which helps to explain the controversy and has clinical implications for resistance management. |
| Publish Date |
2025-08-27 09:21 |
| Citation |
<p>Si LL, Fan ZP, Liu WH, Chen RJ, Chen XY, Ji D, Li L, Chen C, Liao H, Wang J, Xu DP, Zhao J, Liu Y. Hepatitis B virus rtCYE/rtCYEI mutations may contribute limited tenofovir resistance: Analysis of a large sample of Chinese patients. <i>World J Hepatol</i> 2025; 17(8): 107456</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i8/107456.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i8.107456 |
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