BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/27/2025 9:21:10 AM | Browse: 191 | Download: 709
 |
Received |
|
2025-03-31 04:09 |
|
Peer-Review Started |
|
2025-03-31 04:09 |
|
First Decision by Editorial Office Director |
|
2025-04-10 19:49 |
|
Return for Revision |
|
2025-04-11 00:51 |
|
Revised |
|
2025-05-09 14:26 |
|
Publication Fee Transferred |
|
2025-05-17 01:49 |
|
Second Decision by Editor |
|
2025-07-16 02:38 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-07-16 10:26 |
|
Articles in Press |
|
2025-07-16 10:26 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-08-15 03:05 |
|
Publish the Manuscript Online |
|
2025-08-27 09:21 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatitis B virus rtCYE/rtCYEI mutations may contribute limited tenofovir resistance: Analysis of a large sample of Chinese patients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lan-Lan Si, Zhen-Ping Fan, Wen-Hui Liu, Rong-Juan Chen, Xue-Yuan Chen, Dong Ji, Le Li, Chun Chen, Hao Liao, Jun Wang, Dong-Ping Xu, Jun Zhao and Yan Liu |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Yan Liu, PhD, Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, No. 100, Xisihuan Middle Road, Beijing 100039, China. liuyan5360@163.com |
| Key Words |
Hepatitis B virus; Mutation; Tenofovir; Drug resistance; Anti-HBV agents; Hepatitis B virus genotype; Replication capacity |
| Core Tip |
Whether rtS106C+H126Y+D134E/rtS106C+H126Y+D134E+L269I (rtCYE/rtCYEI) mutations in the reverse-transcriptase region of hepatitis B virus (HBV) are associated with tenofovir resistance is controversial. The present study investigated many nucleoside/nucleotide analogue (NA)-treated Chinese patients, focusing on the relationship between rtCYE/rtCYEI mutations and tenofovir resistance. We confirmed that rtCYE/rtCYEI mutations were rare (0.042%) in NAs-treated chronic HBV-infected patients and could appear in tenofovir treatment-naïve patients and remain sensitive to tenofovir. The effect of rtCYE/rtCYEI mutations on tenofovir susceptibility was limited. This study extends the current knowledge related to HBV resistance, which helps to explain the controversy and has clinical implications for resistance management. |
| Publish Date |
2025-08-27 09:21 |
| Citation |
Si LL, Fan ZP, Liu WH, Chen RJ, Chen XY, Ji D, Li L, Chen C, Liao H, Wang J, Xu DP, Zhao J, Liu Y. Hepatitis B virus rtCYE/rtCYEI mutations may contribute limited tenofovir resistance: Analysis of a large sample of Chinese patients. World J Hepatol 2025; 17(8): 107456 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i8/107456.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i8.107456 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
