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7/7/2025 5:57:58 AM | Browse: 3 | Download: 29
Publication Name World Journal of Clinical Cases
Manuscript ID 107471
Country China
Received
2025-03-25 05:12
Peer-Review Started
2025-03-25 05:12
To Make the First Decision
Return for Revision
2025-04-14 10:02
Revised
2025-04-22 10:18
Second Decision
2025-05-23 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-05-24 01:53
Articles in Press
2025-05-24 01:53
Publication Fee Transferred
2025-04-23 02:51
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-07-02 03:17
Publish the Manuscript Online
2025-07-07 05:57
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Otorhinolaryngology
Manuscript Type Case Report
Article Title Unexpected metastasis of thyroid cartilage involvement from lung adenocarcinoma: A case report
Manuscript Source Unsolicited Manuscript
All Author List Mao-Mao Ai, Tao Lin, Ruo-Yu Guo, Ying-Ying Zhang and Feng Yu
ORCID
Author(s) ORCID Number
Mao-Mao Ai http://orcid.org/0009-0007-1653-9173
Tao Lin http://orcid.org/0009-0003-1789-9331
Ruo-Yu Guo http://orcid.org/0009-0009-8550-8287
Ying-Ying Zhang http://orcid.org/0009-0004-3263-1410
Feng Yu http://orcid.org/0000-0002-6948-2509
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technology Projects in Guangzhou 2024A03J0563
Science and Technology Projects in Guangzhou 2023A03J0521
Corresponding Author Mao-Mao Ai, Department of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Gross Hospital, Tongfu Middle Road 396 Haizhu District Guangzhou City Guangdong Province, Guangzhou 510220, Guangdong Province, China. maomao6678@126.com
Key Words Neck neoplasms; Thyroid cartilages; Adenocarcinoma of lung; Case report
Core Tip This rare case documents thyroid cartilage metastasis from an epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (p.E746_S752delinsV) in a 51-year-old smoker. Despite the avascular nature of cartilaginous tissue, the patient presented with neck masses, weight loss, and widespread metastases (pT3N3M1c, stage IVB). First-line gefitinib achieved remarkable regression of cervical, abdominal subcutaneous, and oropharyngeal lesions at 6 months. Key highlights: (1) Thyroid cartilage metastasis, though exceptionally rare, warrants vigilance in lung cancer; (2) EGFR targeting remains effective even in unusual metastatic patterns; and (3) Multidisciplinary management optimizes outcomes. Early molecular testing is critical for tailored therapy.
Publish Date 2025-07-07 05:57
Citation <p>Ai MM, Lin T, Guo RY, Zhang YY, Yu F. Unexpected metastasis of thyroid cartilage involvement from lung adenocarcinoma: A case report. <i>World J Clin Cases</i> 2025; 13(25): 107471</p>
URL https://www.wjgnet.com/2307-8960/full/v13/i25/107471.htm
DOI https://dx.doi.org/10.12998/wjcc.v13.i25.107471
Full Article (PDF) WJCC-13-107471-with-cover.pdf
CARE Checklist–2016 107471-CARE-Checklist-2016.pdf
Manuscript File 107471_Auto_Edited_065809.docx
Answering Reviewers 107471-answering-reviewers.pdf
Audio Core Tip 107471-audio.mp3
Conflict-of-Interest Disclosure Form 107471-conflict-of-interest-statement.pdf
Copyright License Agreement 107471-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 107471-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s) 107471-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 107471-non-native-speakers.pdf
Peer-review Report 107471-peer-reviews.pdf
Scientific Misconduct Check 107471-scientific-misconduct-check.png
Scientific Editor Work List 107471-scientific-editor-work-list.pdf
CrossCheck Report 107471-crosscheck-report.pdf