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        7/7/2025 5:57:58 AM | Browse: 37 | Download: 274
    
    
        
        
    
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                    |  | Received |  | 2025-03-25 05:12 | 
    
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                    |  | Peer-Review Started |  | 2025-03-25 05:12 | 
    
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                    |  | To Make the First Decision |  |  | 
    
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                    |  | Return for Revision |  | 2025-04-14 10:02 | 
    
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                    |  | Revised |  | 2025-04-22 10:18 | 
    
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                    |  | Second Decision |  | 2025-05-23 02:46 | 
    
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                    |  | Accepted by Journal Editor-in-Chief |  |  | 
    
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                    |  | Accepted by Executive Editor-in-Chief |  | 2025-05-24 01:53 | 
    
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                    |  | Articles in Press |  | 2025-05-24 01:53 | 
    
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                    |  | Publication Fee Transferred |  | 2025-04-23 02:51 | 
    
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                    |  | Edit the Manuscript by Language Editor |  |  | 
    
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                    |  | Typeset the Manuscript |  | 2025-07-02 03:17 | 
            
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                            |  | Publish the Manuscript Online |  | 2025-07-07 05:57 | 
        
        
            
                | ISSN | 2307-8960 (online) | 
            
                | Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ | 
            
                | Copyright | The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. | 
                    
                        | Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 | 
            
            
                | Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 | 
            
            
                | Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA | 
            
                | Website | http://www.wjgnet.com | 
        
    
        | Category | Otorhinolaryngology | 
    
        | Manuscript Type | Case Report | 
    
        | Article Title | Unexpected metastasis of thyroid cartilage involvement from lung adenocarcinoma: A case report | 
    
        | Manuscript Source | Unsolicited Manuscript | 
    
        | All Author List | Mao-Mao Ai, Tao Lin, Ruo-Yu Guo, Ying-Ying Zhang and Feng Yu | 
            
                | ORCID |  | 
    
        | Funding Agency and Grant Number | 
                        
                            
                                | Funding Agency | Grant Number |  
                                        | Science and Technology Projects in Guangzhou | 2024A03J0563 |  
                                        | Science and Technology Projects in Guangzhou | 2023A03J0521 |  | 
    
        | Corresponding Author | Mao-Mao Ai, Department of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Gross Hospital, Tongfu Middle Road 396 Haizhu District Guangzhou City Guangdong Province, Guangzhou 510220, Guangdong Province, China. maomao6678@126.com | 
    
        | Key Words | Neck neoplasms; Thyroid cartilages; Adenocarcinoma of lung; Case report | 
    
        | Core Tip | This rare case documents thyroid cartilage metastasis from an epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (p.E746_S752delinsV) in a 51-year-old smoker. Despite the avascular nature of cartilaginous tissue, the patient presented with neck masses, weight loss, and widespread metastases (pT3N3M1c, stage IVB). First-line gefitinib achieved remarkable regression of cervical, abdominal subcutaneous, and oropharyngeal lesions at 6 months. Key highlights: (1) Thyroid cartilage metastasis, though exceptionally rare, warrants vigilance in lung cancer; (2) EGFR targeting remains effective even in unusual metastatic patterns; and (3) Multidisciplinary management optimizes outcomes. Early molecular testing is critical for tailored therapy. | 
            
                | Publish Date | 2025-07-07 05:57 | 
    
        | Citation | <p>Ai MM, Lin T, Guo RY, Zhang YY, Yu F. Unexpected metastasis of thyroid cartilage involvement from lung adenocarcinoma: A case report. <i>World J Clin Cases</i> 2025; 13(25): 107471</p> | 
            
                | URL | https://www.wjgnet.com/2307-8960/full/v13/i25/107471.htm | 
            
                | DOI | https://dx.doi.org/10.12998/wjcc.v13.i25.107471 | 
    
    
        
                
        
     
 
                 
             
         
        
    
        
        
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