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7/22/2025 8:44:58 AM | Browse: 6 | Download: 31
Publication Name World Journal of Cardiology
Manuscript ID 107539
Country United States
Received
2025-03-26 03:58
Peer-Review Started
2025-03-26 03:59
To Make the First Decision
Return for Revision
2025-04-25 09:12
Revised
2025-04-29 14:50
Second Decision
2025-06-16 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-06-16 11:09
Articles in Press
2025-06-16 11:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-07-11 03:52
Publish the Manuscript Online
2025-07-22 08:44
ISSN 1949-8462 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Minireviews
Article Title Breaking barriers: Neprilysin inhibition in chronic cardiorenal syndrome
Manuscript Source Invited Manuscript
All Author List Olesya Ilkun and Amir Kazory
ORCID
Author(s) ORCID Number
Amir Kazory http://orcid.org/0000-0001-8853-0572
Funding Agency and Grant Number
Corresponding Author Amir Kazory, Professor, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, 1600 Sw Archer Rd Box 100224, Gainesville, FL 32610, United States. amir.kazory@medicine.ufl.edu
Key Words Neprilysin inhibitor; Sacubitril/valsartan; Heart failure; Chronic kidney disease; End-stage kidney disease
Core Tip Patients with advanced chronic kidney disease and end-stage kidney disease face disproportionally high rates of heart failure and mortality. Currently, there is an unmet need for medical therapies for heart failure in these populations. This review summarizes information regarding the safety and efficacy of the use of angiotensin receptor/neprilysin inhibition in patients with heart failure with reduced ejection fraction and advanced chronic kidney disease or end-stage kidney disease to help guide safe clinical management.
Publish Date 2025-07-22 08:44
Citation <p>Ilkun O, Kazory A. Breaking barriers: Neprilysin inhibition in chronic cardiorenal syndrome. <i>World J Cardiol</i> 2025; 17(7): 107539</p>
URL https://www.wjgnet.com/1949-8462/full/v17/i7/107539.htm
DOI https://dx.doi.org/10.4330/wjc.v17.i7.107539
Full Article (PDF) WJC-17-107539-with-cover.pdf
Manuscript File 107539_Auto_Edited_073249.docx
Answering Reviewers 107539-answering-reviewers.pdf
Audio Core Tip 107539-audio.m4a
Conflict-of-Interest Disclosure Form 107539-conflict-of-interest-statement.pdf
Copyright License Agreement 107539-copyright-assignment.pdf
Peer-review Report 107539-peer-reviews.pdf
Scientific Misconduct Check 107539-scientific-misconduct-check.png
Scientific Editor Work List 107539-scientific-editor-work-list.pdf
CrossCheck Report 107539-crosscheck-report.pdf