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        7/25/2025 12:09:48 PM | Browse: 49 | Download: 113
    
    
        
        
    
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                    |  | Received |  | 2025-03-26 03:46 | 
    
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                    |  | Peer-Review Started |  | 2025-03-28 00:12 | 
    
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                    |  | To Make the First Decision |  |  | 
    
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                    |  | Return for Revision |  | 2025-04-28 09:21 | 
    
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                    |  | Revised |  | 2025-05-05 14:38 | 
    
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                    |  | Second Decision |  | 2025-06-27 02:39 | 
    
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                    |  | Accepted by Journal Editor-in-Chief |  |  | 
    
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                    |  | Accepted by Executive Editor-in-Chief |  | 2025-06-27 07:22 | 
    
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                    |  | Articles in Press |  | 2025-06-27 07:22 | 
    
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                    |  | Publication Fee Transferred |  |  | 
    
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                    |  | Edit the Manuscript by Language Editor |  | 2025-07-03 23:20 | 
    
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                    |  | Typeset the Manuscript |  | 2025-07-16 03:25 | 
            
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                            |  | Publish the Manuscript Online |  | 2025-07-25 12:09 | 
        
        
            
                | ISSN | 1948-5182 (online) | 
            
                | Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ | 
            
                | Copyright | © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. | 
                    
                        | Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 | 
            
            
                | Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 | 
            
            
                | Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA | 
            
                | Website | http://www.wjgnet.com | 
        
    
        | Category | Gastroenterology & Hepatology | 
    
        | Manuscript Type | Review | 
    
        | Article Title | Liver immunology: Biological role and clinical significance | 
    
        | Manuscript Source | Invited Manuscript | 
    
        | All Author List | Stanislav Nikolaevich Kotlyarov | 
            
                | ORCID |  | 
    
        | Funding Agency and Grant Number |  | 
    
        | Corresponding Author | Stanislav Nikolaevich Kotlyarov, PhD, Professor, Department of Nurse, Ryazan State Medical University, 9 Vysokovoltnaya, Ryazan 390005, Russia. skmr1@yandex.ru | 
    
        | Key Words | Liver; Immunology; Immunometabolism; Innate immune system; Adaptive immune system; Immune cells; Metabolic dysfunction-associated steatotic liver disease; Biliary diseases; Gut microbiota | 
    
        | Core Tip | The liver is an important organ at the intersection of many metabolic and immune pathways. Immune cells in the liver have a complex regulation that can be impaired in various diseases such as metabolic dysfunction-associated steatotic liver disease, liver cancer, and biliary disorders. Interactions with the gut microbiota play an important role in liver immunology. Effects on immune mechanisms are considered a promising therapeutic target for liver diseases. | 
            
                | Publish Date | 2025-07-25 12:09 | 
    
        | Citation | <p>Kotlyarov SN. Liver immunology: Biological role and clinical significance. <i>World J Hepatol</i> 2025; 17(7): 107541</p> | 
            
                | URL | https://www.wjgnet.com/1948-5182/full/v17/i7/107541.htm | 
            
                | DOI | https://dx.doi.org/10.4254/wjh.v17.i7.107541 | 
    
    
        
                
        
     
 
                 
             
         
        
    
        
        
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