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Articles Published Processes
5/20/2025 3:37:35 AM | Browse: 20 | Download: 61
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Received |
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2025-03-27 02:35 |
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Peer-Review Started |
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2025-03-27 02:36 |
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To Make the First Decision |
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Return for Revision |
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2025-04-01 07:24 |
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Revised |
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2025-04-02 03:55 |
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Second Decision |
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2025-04-24 02:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-24 11:13 |
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Articles in Press |
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2025-04-24 11:13 |
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Publication Fee Transferred |
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2025-04-03 02:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-08 00:52 |
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Publish the Manuscript Online |
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2025-05-20 03:37 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Serum pro-inflammatory cytokines as potential biomarkers for the diagnosis of gastric carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Le Ren, Jun Liu, Ya-Yun Xu and Zhen-Wang Shi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhen-Wang Shi, Professor, Department of Gastroenterology, Second People's Hospital of Hefei, Heping Road, Hefei 230011, Anhui Province, China. shiyitao99@163.com |
| Key Words |
Gastric carcinoma; Pro-inflammatory cytokines; Serum; Biomarker; Diagnosis |
| Core Tip |
This investigation compared the concentrations of seven pro-inflammatory cytokines between gastric carcinoma (GC) patients and healthy controls, aiming to identify serum cytokine-based biomarkers for GC. The study produced four main findings. Firstly, GC patients demonstrated elevated levels of interleukin (IL)-1β, IL-6, IL-8, and interferon-γ compared to controls. Secondly, receiver operating characteristic curve analysis indicated that the area under the curve values for IL-1β, IL-6, and IL-8 exceeded 0.7 in differentiating GC patients from healthy individuals. Thirdly, serum levels of IL-1β and IL-6 showed a positive correlation with the T stage of the disease. Fourthly, the serum concentrations of IL-1β and IL-6 were positively associated with the N stage. These findings suggest that circulating pro-inflammatory cytokines, such as IL-1β, IL-6, and IL-8, may serve as potential biomarkers for the diagnosis of GC. |
| Publish Date |
2025-05-20 03:37 |
| Citation |
<p>Ren L, Liu J, Xu YY, Shi ZW. Serum pro-inflammatory cytokines as potential biomarkers for the diagnosis of gastric carcinoma. <i>World J Clin Oncol</i> 2025; 16(5): 107551</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i5/107551.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i5.107551 |
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