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7/17/2025 8:43:48 AM | Browse: 41 | Download: 178
Publication Name World Journal of Orthopedics
Manuscript ID 107575
Country United Kingdom
Received
2025-03-26 04:24
Peer-Review Started
2025-03-26 04:24
First Decision by Editorial Office Director
2025-04-09 01:50
Return for Revision
2025-04-09 01:50
Revised
2025-04-18 10:26
Publication Fee Transferred
Second Decision by Editor
2025-06-03 02:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-06-03 11:19
Articles in Press
2025-06-03 11:19
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-07-09 07:17
Publish the Manuscript Online
2025-07-17 08:43
ISSN 2218-5836 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Minireviews
Article Title Defensive antibacterial coating in orthopaedic surgery: Current evidence and future direction
Manuscript Source Invited Manuscript
All Author List Richard Henry Randall Roberts, Charles Gamble and Ibrahim Malek
ORCID
Author(s) ORCID Number
Richard Henry Randall Roberts http://orcid.org/0000-0002-9600-5943
Charles Gamble http://orcid.org/0009-0005-4845-5885
Funding Agency and Grant Number
Corresponding Author Richard Henry Randall Roberts, Research Fellow, Department of Trauma and Orthopaedics, Wrexham Maelor Hospital, Croesnewydd Rd, Wrexham LL13 7TD, United Kingdom. richard.roberts@doctors.org.uk
Key Words Patient outcomes; Revision arthroplasty; Biofilm prevention; Defensive antibacterial coating; Antibiotic prophylaxis; Orthopaedic surgery; Implant-related infections; Periprosthetic joint infections; Surgical site infections; Hospital-acquired infections
Core Tip Orthopaedic implant-related infections, including prosthetic joint and osteosynthesis-associated infections, significantly burden healthcare systems clinically and economically. Defensive antibacterial coating (DAC®) hydrogel emerges as a promising bioresorbable adjunct to traditional prophylactic strategies, effectively reducing infection rates and antibiotic overuse in orthopaedic surgery. While robust evidence supports DAC® in revision arthroplasty and trauma surgery, further high-quality studies are needed to confirm its role in primary joint replacement and expand applications to diverse patient populations and anatomical sites.
Publish Date 2025-07-17 08:43
Citation

Roberts RHR, Gamble C, Malek I. Defensive antibacterial coating in orthopaedic surgery: Current evidence and future direction. World J Orthop 2025; 16(7): 107575

URL https://www.wjgnet.com/2218-5836/full/v16/i7/107575.htm
DOI https://dx.doi.org/10.5312/wjo.v16.i7.107575
Full Article (PDF) WJO-16-107575-with-cover.pdf
Manuscript File 107575_Auto_Edited_055925.docx
Answering Reviewers 107575-answering-reviewers.pdf
Audio Core Tip 107575-audio.m4a
Conflict-of-Interest Disclosure Form 107575-conflict-of-interest-statement.pdf
Copyright License Agreement 107575-copyright-assignment.pdf
Peer-review Report 107575-peer-reviews.pdf
Scientific Editor Work List 107575-scientific-editor-work-list.pdf
CrossCheck Report 107575-crosscheck-report.pdf