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Articles Published Processes
7/25/2025 12:09:43 PM | Browse: 14 | Download: 38
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Received |
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2025-03-27 03:53 |
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Peer-Review Started |
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2025-04-06 08:36 |
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To Make the First Decision |
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Return for Revision |
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2025-04-16 10:45 |
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Revised |
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2025-04-29 07:58 |
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Second Decision |
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2025-06-20 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-20 09:47 |
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Articles in Press |
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2025-06-20 09:47 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-06-23 02:51 |
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Typeset the Manuscript |
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2025-07-16 03:26 |
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Publish the Manuscript Online |
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2025-07-25 12:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Minireviews |
| Article Title |
Splenectomy and the risk of hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Da-Qing Li, Zhen-Yi Lin, Jian-Guo Wang, Rong-Qian Wu, Yu Zhang and Zhao-Qing Du |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82200686 |
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| Corresponding Author |
Zhao-Qing Du, Academic Editor, MD, PhD, Post Doctoral Researcher, Researcher, Department of Hepatobiliary Surgery, Shaanxi Provincial People’s Hospital, No. 256 West Youyi Road, Xi’an 710068, Shaanxi Province, China. duzhaoqing2007@126.com |
| Key Words |
Splenectomy; Hepatocellular carcinoma; Immune status; Hemodynamics; Pathophysiology |
| Core Tip |
Hypersplenism, a frequent complication of cirrhosis, often requires splenectomy to alleviate conditions like thrombocytopenia and anemia. However, splenectomy may alter immune status and hemodynamics, potentially influencing hepatocellular carcinoma (HCC) development. Post-splenectomy risks, including infections and thrombosis, further complicate outcomes. Current evidence on the splenectomy-HCC relationship remains inconclusive, necessitating further research into pathophysiology and epidemiology. This review examines immune, hemodynamic, and gut microbiota changes post-splenectomy to guide individualized treatment strategies for cirrhotic patients. |
| Publish Date |
2025-07-25 12:09 |
| Citation |
<p>Li DQ, Lin ZY, Wang JG, Wu RQ, Zhang Y, Du ZQ. Splenectomy and the risk of hepatocellular carcinoma. <i>World J Hepatol</i> 2025; 17(7): 107603</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i7/107603.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i7.107603 |
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