| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Genetically engineered mouse models in gastric precancerous lesions research
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi Quan, Yue-Bo Jia, Chen-Heng Wu, Qing-Ling Jia, Yong-Qi Chen, Zhi-Jian Gu and Jiang-Hong Ling |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Administration of Traditional Chinese Medicine National Superior Specialty Project of Traditional Chinese Medicine |
No. [2024] 90 |
| Shanghai Municipal Administrator of Traditional Chinese Medicine Policy Letter [2024] |
No. 20 |
| Science and Technology Development Fund of Shanghai University of Traditional Chinese Medicine |
No. 23KFL102 |
| Shuguang Hospital Siming Foundation Research Special Project |
No. SGKJ-202304 |
|
| Corresponding Author |
Jiang-Hong Ling, MD, Professor, Department of Gastroenterology, Shuguang Affiliated Hospital, Shanghai University of Traditional Chinese Medicine, No. 185 Pu’an Road, Huangpu District, Shanghai 200021, China. 459183870@qq.com |
| Key Words |
Precancerous lesions of gastric cancer; Atrophic gastritis; Intestinal metaplasia; Dysplasia; Genetically engineered mice; Pathogenesis |
| Core Tip |
Precancerous lesions of gastric cancer refer to a series of pathological changes in the gastric mucosa, including atrophic gastritis, intestinal metaplasia, and dysplasia. These lesions are significant risk factors for the development of gastric carcinoma. Genetically engineered mice, modified through techniques such as gene knockout, gene knock-in, transgenesis, and point mutation, are utilized to investigate gene function, disease mechanisms, and to develop novel therapeutic strategies. This review discusses the genetically engineered mouse models employed in the study of precancerous lesions of gastric cancer, with an emphasis on elucidating their pathological mechanisms. |
| Publish Date |
2025-07-23 11:11 |
| Citation |
<p>Quan Y, Jia YB, Wu CH, Jia QL, Chen YQ, Gu ZJ, Ling JH. Genetically engineered mouse models in gastric precancerous lesions research. <i>World J Gastrointest Surg</i> 2025; 17(7): 107610</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i7/107610.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i7.107610 |
