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6/16/2025 6:25:06 AM | Browse: 6 | Download: 47
Publication Name World Journal of Clinical Cases
Manuscript ID 107612
Country Greece
Received
2025-03-27 02:30
Peer-Review Started
2025-03-27 02:30
To Make the First Decision
Return for Revision
2025-04-11 09:51
Revised
2025-04-17 15:43
Second Decision
2025-05-09 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-05-10 02:08
Articles in Press
2025-05-10 02:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-05-30 13:02
Publish the Manuscript Online
2025-06-16 06:25
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Letter to the Editor
Article Title Endocrine dysfunction in homozygous beta-thalassemia: An underrecognized and undertreated consequence of prolonged survival
Manuscript Source Unsolicited Manuscript
All Author List Christos Savvidis and Ioannis Ilias
ORCID
Author(s) ORCID Number
Christos Savvidis http://orcid.org/0000-0002-0188-1685
Ioannis Ilias http://orcid.org/0000-0001-5718-7441
Funding Agency and Grant Number
Corresponding Author Ioannis Ilias, Department of Endocrinology, Hippocration General Hospital, No. 63 Evrou Street, Athens GR-11527, Greece. iiliasmd@yahoo.com
Key Words Thalassemia, Endocrine dysfunction; Iron overload; Hypogonadotropic hypogonadism; Adrenal insufficiency; Thyroid dysfunction; Bone disease
Core Tip Endocrine dysfunction is a major source of long-term morbidity in transfusion-dependent beta-thalassemia. Subtle hypothalamic-pituitary axis abnormalities, such as neurosecretory growth hormone dysfunction and tertiary adrenal insufficiency, may precede overt clinical signs. Pituitary magnetic resonance imaging and dynamic hormone testing improve early detection. Integrating routine endocrine screening into thalassemia care enables timely interventions that can prevent irreversible complications and enhance quality of life.
Publish Date 2025-06-16 06:25
Citation <p>Savvidis C, Ilias I. Endocrine dysfunction in homozygous beta-thalassemia: An underrecognized and undertreated consequence of prolonged survival. <i>World J Clin Cases</i> 2025; 13(24): 107612</p>
URL https://www.wjgnet.com/2307-8960/full/v13/i24/107612.htm
DOI https://dx.doi.org/10.12998/wjcc.v13.i24.107612
Full Article (PDF) WJCC-13-107612-with-cover.pdf
Manuscript File 107612_Auto_Edited_062100.docx
Answering Reviewers 107612-answering-reviewers.pdf
Audio Core Tip 107612-audio.mp3
Conflict-of-Interest Disclosure Form 107612-conflict-of-interest-statement.pdf
Copyright License Agreement 107612-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 107612-non-native-speakers.pdf
Peer-review Report 107612-peer-reviews.pdf
Scientific Misconduct Check 107612-scientific-misconduct-check.png
Scientific Editor Work List 107612-scientific-editor-work-list.pdf
CrossCheck Report 107612-crosscheck-report.pdf