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Articles Published Processes
9/15/2025 8:37:59 AM | Browse: 185 | Download: 158
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Received |
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2025-03-28 02:43 |
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Peer-Review Started |
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2025-03-28 02:43 |
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First Decision by Editorial Office Director |
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2025-04-02 06:45 |
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Return for Revision |
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2025-04-04 00:10 |
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Revised |
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2025-05-03 08:25 |
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Publication Fee Transferred |
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2025-05-08 02:05 |
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Second Decision by Editor |
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2025-06-30 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-06-30 09:24 |
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Articles in Press |
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2025-06-30 09:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-25 02:56 |
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Publish the Manuscript Online |
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2025-09-15 08:37 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Relationship between uric acid and colon cancer risk: Dose-response analysis and mechanisms
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Teng-Fei Sun, Ke-Xin Fan, Yu-Xin Luo, Jia Song, Zhuo-Xiao Han and Xiao-Lan Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Lan Zhang, Professor, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, No. 80 Huanghe Road, Yuhua District, Shijiazhuang 050000, Hebei Province, China. xiaolanzh@hebmu.edu.cn |
| Key Words |
Uric acid; Colon cancer; Reactive oxygen species; Phosphoinositide 3-kinases; Mammalian target of rapamycin |
| Core Tip |
This study, encompassing 2020 colon cancer cases and 6060 controls, revealed an inverse association between uric acid levels and the risk of colon cancer. To delve deeper into the underlying mechanisms, we conducted in vitro experiments using colon cancer cells. Our findings demonstrated that uric acid potently inhibits cell proliferation and migration. Mechanistically, these effects were mediated by the induction of reactive oxygen species and the suppression of the phosphoinositide 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway. |
| Publish Date |
2025-09-15 08:37 |
| Citation |
Sun TF, Fan KX, Luo YX, Song J, Han ZX, Zhang XL. Relationship between uric acid and colon cancer risk: Dose-response analysis and mechanisms. World J Gastrointest Oncol 2025; 17(9): 107651 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i9/107651.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i9.107651 |
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