| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Tumor necrosis factor alpha-induced protein 3: A key biomarker for response to ursodeoxycholic acid in primary biliary cholangitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo Zang, Jia-Xiu Li, Qi-Xuan Liu, Yuan Yao, Hua Li, Yan Wang, Ji-Gang Wang, Yi-Fei Yang, Rui-Wen Liang, Xin-Ran Xin and Bin Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81671600 and No. 81241094 |
| Natural Science Foundation of Shandong Province, China |
No. ZR2016HM13 and No. ZR2023MH066 |
| Qingdao Medical and Health Scientific Research Project, China |
No. 2024-WJKY160 |
|
| Corresponding Author |
Bin Liu, MD, PhD, Department of Rheumatology and Immunology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266001, Shandong Province, China. binliu72314@163.com |
| Key Words |
Primary biliary cholangitis; Bioinformatics analysis; Tumor necrosis factor alpha-induced protein 3; Biomarkers; Predictor; Therapeutic target |
| Core Tip |
By bioinformatics analysis, we identified 13 differentially expressed genes linked to primary biliary cholangitis progression. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) was selected for validation via immunohistochemistry and confirmed as a promising biomarker for ursodeoxycholic acid response. Clinical validation further proved its significant correlation with treatment outcomes. Additionally, fatigue was identified as an independent predictor of ursodeoxycholic acid efficacy, and the combination of TNFAIP3 expression and fatigue exhibited superior predictive performance. The expression of TNFAIP3 was also associated with key clinicopathological features, including age, albumin levels, total bilirubin, alkaline phosphatase, and splenomegaly, providing new insights into disease progression. |
| Publish Date |
2025-07-25 12:09 |
| Citation |
<p>Zang B, Li JX, Liu QX, Yao Y, Li H, Wang Y, Wang JG, Yang YF, Liang RW, Xin XR, Liu B. Tumor necrosis factor alpha-induced protein 3: A key biomarker for response to ursodeoxycholic acid in primary biliary cholangitis. <i>World J Hepatol</i> 2025; 17(7): 107666</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i7/107666.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i7.107666 |
