Publication Name	World Journal of Hepatology
Manuscript ID	107668
Country	Mexico

Received	2025-03-30 11:29
Peer-Review Started	2025-03-30 11:29
To Make the First Decision
Return for Revision	2025-04-21 18:38
Revised	2025-05-04 14:39
Second Decision	2025-06-25 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-25 08:23
Articles in Press	2025-06-25 08:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-28 20:05
Typeset the Manuscript	2025-07-16 01:12
Publish the Manuscript Online	2025-07-25 12:09

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Triglyceride-glucose-waist circumference index: A powerful tool for metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Bryan Adrian Priego-Parra, Berenice M Román-Calleja, Rocio Gallego-Duran, Jordi Gracia-Sancho, Jose Antonio Velarde Ruiz-Velasco and Jose Maria Remes-Troche
ORCID	Author(s) ORCID Number Bryan Adrian Priego-Parra http://orcid.org/0000-0003-1506-806X Berenice M Román-Calleja http://orcid.org/0000-0001-7624-9679 Rocio Gallego-Duran http://orcid.org/0000-0002-9452-1661 Jordi Gracia-Sancho http://orcid.org/0000-0001-7736-4089 Jose Antonio Velarde Ruiz-Velasco http://orcid.org/0000-0002-6568-7048 Jose Maria Remes-Troche http://orcid.org/0000-0001-8478-9659
Funding Agency and Grant Number
Corresponding Author	Bryan Adrian Priego-Parra, MD, PhD, Department of Digestive Physiology and Gastrointestinal Motility, Institute of Medical-Biological Research, Universidad Veracruzana, Iturbide S/N Entre Carmen Serdán y 20 de Noviembre, Veracruz 91700, Mexico. bryanpriegop@gmail.com
Key Words	Steatotic liver disease; Liver steatosis; Non-invasive; Biomarkers; Nutritional therapy; Cardiometabolic risk
Core Tip	The search for reliable biomarkers for metabolic dysfunction-associated steatotic liver disease (MASLD) remains a critical priority. Among non-invasive and accessible tools, the triglyceride-glucose-waist circumference index (TyG-WC) has emerged as a particularly robust marker, demonstrating superior diagnostic performance compared with other indices. Its utility extends beyond MASLD, offering valuable insights into cardiovascular risk and other extrahepatic manifestations. Given its simplicity and affordability, the TyG-WC index holds significant promise, particularly in low-resource settings. Nonetheless, longitudinal studies are needed to validate its predictive capacity and guide clinical implementation. Integrating this index within clinical and research frameworks, alongside investigations into the gut microbiota, multiomic profiling, and artificial intelligence, may unlock new pathways for improving MASLD diagnosis and management.
Publish Date	2025-07-25 12:09
Citation	<p>Priego-Parra BA, Román-Calleja BM, Gallego-Duran R, Gracia-Sancho J, Velarde Ruiz-Velasco JA, Remes-Troche JM. Triglyceride-glucose-waist circumference index: A powerful tool for metabolic dysfunction-associated steatotic liver disease. <i>World J Hepatol</i> 2025; 17(7): 107668</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i7/107668.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i7.107668

Full Article (PDF)	WJH-17-107668-with-cover.pdf
Manuscript File	107668_Auto_Edited_020736.docx
Answering Reviewers	107668-answering-reviewers.pdf
Audio Core Tip	107668-audio.mp4
Conflict-of-Interest Disclosure Form	107668-conflict-of-interest-statement.pdf
Copyright License Agreement	107668-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	107668-non-native-speakers.pdf
Supplementary Material	107668-supplementary-material.pdf
Peer-review Report	107668-peer-reviews.pdf
Scientific Misconduct Check	107668-scientific-misconduct-check.png
Scientific Editor Work List	107668-scientific-editor-work-list.pdf
CrossCheck Report	107668-crosscheck-report.pdf