Publication Name	World Journal of Psychiatry
Manuscript ID	107726
Country	Slovenia

Received	2025-03-28 04:32
Peer-Review Started	2025-03-31 01:36
To Make the First Decision
Return for Revision	2025-04-03 08:46
Revised	2025-04-15 11:37
Second Decision	2025-06-11 03:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-18 07:17
Articles in Press	2025-06-18 07:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-07-08 19:43
Typeset the Manuscript	2025-08-15 06:38
Publish the Manuscript Online	2025-08-26 10:18

ISSN	2220-3206 (online)
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Category	Psychiatry
Manuscript Type	Review
Article Title	Epigenetics and immunology: Under-recognized aspects of suicidality
Manuscript Source	Invited Manuscript
All Author List	Katarina Kouter, Julija Šmon and Alja Videtič Paska
ORCID	Author(s) ORCID Number Katarina Kouter http://orcid.org/0000-0002-1051-959X Julija Šmon http://orcid.org/0000-0002-2703-832X Alja Videtič Paska http://orcid.org/0000-0002-1182-5417
Funding Agency and Grant Number	Funding Agency Grant Number Slovenian Research and Innovation Agency Program P1-0390 and N3-0349 Slovenian Research and Innovation Agency Program, Young Researcher Grant
Corresponding Author	Alja Videtič Paska, Full Professor, PhD, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Vrazov Trg 2, Ljubljana 1000, Slovenia. alja.videtic@mf.uni-lj.si
Key Words	Suicide; Suicidal behavior; Inflammation; DNA methylation; Histone tail modification; Non-coding RNA; Multiomics; Adverse childhood experiences
Core Tip	Suicidality is heterogeneous and cannot fully be accounted for by psychiatric comorbidities. To understand its biological background, it is important to consider epigenetic regulation as a mediator of suicide risk in response to environmental stimuli, particularly early life adversity. Chronic inflammation has been implicated in neuropsychiatric disorders, and further research of whether suicidality associates with a specific inflammatory profile is warranted. The interactions between immune system dysregulation, stress response and epigenetics hold promise for biomarker discovery, but are insufficiently explored. To accelerate the development of targeted suicide prevention strategies, stringent sample selection and integrative multi-omics approaches should be applied.
Publish Date	2025-08-26 10:18
Citation	<p>Kouter K, Šmon J, Videtič Paska A. Epigenetics and immunology: Under-recognized aspects of suicidality. <i>World J Psychiatry</i> 2025; 15(9): 107726</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i9/107726.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i9.107726

Full Article (PDF)	WJP-15-107726-with-cover.pdf
Manuscript File	107726_Auto_Edited_014208.docx
Answering Reviewers	107726-answering-reviewers.pdf
Audio Core Tip	107726-audio.m4a
Conflict-of-Interest Disclosure Form	107726-conflict-of-interest-statement.pdf
Copyright License Agreement	107726-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	107726-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	107726-non-native-speakers.pdf
Peer-review Report	107726-peer-reviews.pdf
Scientific Misconduct Check	107726-scientific-misconduct-check.png
Scientific Editor Work List	107726-scientific-editor-work-list.pdf
CrossCheck Report	107726-crosscheck-report.pdf