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Articles Published Processes
8/27/2025 9:21:13 AM | Browse: 62 | Download: 112
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Received |
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2025-04-09 11:13 |
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Peer-Review Started |
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2025-04-18 08:58 |
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To Make the First Decision |
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Return for Revision |
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2025-05-12 08:28 |
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Revised |
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2025-05-21 13:09 |
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Second Decision |
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2025-07-23 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-23 10:29 |
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Articles in Press |
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2025-07-23 10:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-13 03:50 |
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Publish the Manuscript Online |
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2025-08-27 09:21 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Minireviews |
| Article Title |
Vitamin A toxicity and hepatic pathology: A comprehensive review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
María L Pestalardo, Cecilia S Bevilacqua and Marcelo Fabián Amante |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marcelo Fabián Amante, Chief Physician, MD, Professor, División Patología, Hospital General de Agudos Cosme Argerich, Pi y Margall 480, Buenos Aires C1155AHA, Argentina. marcelofabianamante@gmail.com |
| Key Words |
Hypervitaminosis A; Hepatic fibrosis; Oxidative stress; Stellate cells; Retinoids; Cirrhosis |
| Core Tip |
Vitamin A toxicity (hypervitaminosis A) causes serious liver damage, progressing from steatosis to fibrosis and cirrhosis. The liver’s storage capacity is overwhelmed, leading to retinoid accumulation, oxidative stress, and inflammation. Key mechanisms include reactive oxygen species generation, apoptosis, and dysregulated pathways (tumor growth factor-beta, nuclear factor-kappa B), which drive stellate cell activation and fibrosis. Clinically, chronic toxicity manifests as hepatomegaly, portal hypertension, and potential liver failure. Management involves limiting vitamin A intake and exploring antioxidants (e.g., N-acetylcysteine) or anti-fibrotic therapies. Future research should focus on biomarkers, personalized risk assessment, and safer dietary guidelines. Public awareness and therapeutic advancements are crucial to prevent liver disease. |
| Publish Date |
2025-08-27 09:21 |
| Citation |
<p>Pestalardo ML, Bevilacqua CS, Amante MF. Vitamin A toxicity and hepatic pathology: A comprehensive review. <i>World J Hepatol</i> 2025; 17(8): 107738</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i8/107738.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i8.107738 |
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