Publication Name	World Journal of Stem Cells
Manuscript ID	107770
Country	China

Received	2025-03-31 07:33
Peer-Review Started	2025-03-31 07:33
To Make the First Decision
Return for Revision	2025-04-23 11:47
Revised	2025-05-06 08:19
Second Decision	2025-07-03 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-03 07:23
Articles in Press	2025-07-03 07:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-15 13:15
Publish the Manuscript Online	2025-07-24 09:11

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Nutrient sensing in intestinal stem cell: Linking dietary nutrients to cellular metabolic regulation
Manuscript Source	Invited Manuscript
All Author List	Wen-Hao Li, Xin-Yi Yuan, Zhe Wang and Rong Lin
ORCID	Author(s) ORCID Number Wen-Hao Li http://orcid.org/0009-0005-4228-2848 Zhe Wang http://orcid.org/0000-0002-3289-6134 Rong Lin http://orcid.org/0000-0001-6649-8751
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Technology of China 2022YFF1203300 National Key Research and Development Program 2023YFC2307001 China Postdoctoral Science Foundation 2023TQ0125, 2024M751031
Corresponding Author	Rong Lin, Professor, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. 2009xh0877@hust.edu.cn
Key Words	Intestinal stem cell; Intestinal organoids; Nutrient sensing; Metabolic regulation; Mitochondria
Core Tip	Diet and nutrition play a critical role in health by regulating intestinal nutrient absorption, with intestinal stem cells serving as the central link between nutrient metabolism and intestinal tissue renewal. Nutrient sensing, metabolic regulation, and mitochondrial function are key determinants of intestinal stem cell fate, balancing self-renewal and differentiation. Understanding these mechanisms offers insights into stem cell-based therapies for gastrointestinal diseases and dietary interventions to promote health.
Publish Date	2025-07-24 09:11
Citation	<p>Li WH, Yuan XY, Wang Z, Lin R. Nutrient sensing in intestinal stem cell: Linking dietary nutrients to cellular metabolic regulation. <i>World J Stem Cells</i> 2025; 17(7): 107770</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i7/107770.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i7.107770

Full Article (PDF)	WJSC-17-107770-with-cover.pdf
Manuscript File	107770_Auto_Edited_022745.docx
Answering Reviewers	107770-answering-reviewers.pdf
Audio Core Tip	107770-audio.mp3
Conflict-of-Interest Disclosure Form	107770-conflict-of-interest-statement.pdf
Copyright License Agreement	107770-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	107770-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	107770-non-native-speakers.pdf
Peer-review Report	107770-peer-reviews.pdf
Scientific Misconduct Check	107770-scientific-misconduct-check.png
Scientific Editor Work List	107770-scientific-editor-work-list.pdf
CrossCheck Report	107770-crosscheck-report.pdf