| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Discovering a new paradigm: Gut microbiota as a central modulator of sexual health
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Giuseppe Marano, Maria B Anesini, Miriam Milintenda, Mariateresa Acanfora, Claudia d’Abate, Francesco M Lisci, Ilaria Pirona, Gianandrea Traversi, Roberto Pola, Eleonora Gaetani and Marianna Mazza |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marianna Mazza, Assistant Professor, MD, PhD, Department of Neurosciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo A Gemelli 8, Rome 00168, Italy. mariannamazza@hotmail.com |
| Key Words |
Gut microbiota; Sexual health; Mental health; Dysbiosis; Gut brain axis; Short-chain fatty acids; Neurotransmitters; Hormonal regulation; Sexual performance anxiety; Diet; Psychobiotics; Psychological therapies |
| Core Tip |
The gut microbiota is crucial for sexual health, influencing hormonal balance, immune function, and the gut-brain axis. A balanced microbiota supports optimal levels of estro-gen and testosterone, while dysbiosis contributes to erectile dysfunction, polycystic ovary syndrome and decreased libido. Microbial metabolites, such as short-chain fatty acids, influence neurotransmitters and mood, affecting sexual desire and function. Therapeutic approaches, including probiotics, prebiotics, and fecal microbiota transplantation, show promise in restoring gut balance and improving sexual health. Recognizing this interplay offers new strategies for managing sexual dysfunctions and enhancing overall well-being. |
| Publish Date |
2025-09-19 09:29 |
| Citation |
<p>Marano G, Anesini MB, Milintenda M, Acanfora M, d’Abate C, Lisci FM, Pirona I, Traversi G, Pola R, Gaetani E, Mazza M. Discovering a new paradigm: Gut microbiota as a central modulator of sexual health. <i>World J Gastrointest Pathophysiol</i> 2025; 16(3): 107823</p> |
| URL |
https://www.wjgnet.com/2150-5330/full/v16/i3/107823.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v16.i3.107823 |
