Publication Name	World Journal of Hepatology
Manuscript ID	107837
Country	Brazil

Received	2025-04-01 15:20
Peer-Review Started	2025-04-02 08:46
To Make the First Decision
Return for Revision	2025-04-14 10:41
Revised	2025-04-30 11:42
Second Decision	2025-07-07 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-07 07:13
Articles in Press	2025-07-07 07:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-16 03:29
Publish the Manuscript Online	2025-07-25 12:09

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Are we standing on the shifting sands of post-transplant metabolic-associated steatotic liver disease?
Manuscript Source	Invited Manuscript
All Author List	Renata Zatta, Luana Santiago da Silva, Guilherme Felga and Carolina Frade Girardin Pimentel
ORCID	Author(s) ORCID Number Renata Zatta http://orcid.org/0009-0001-8415-8299 Luana Santiago da Silva http://orcid.org/0000-0002-3798-6534 Guilherme Felga http://orcid.org/0000-0002-0676-4867 Carolina Frade Girardin Pimentel http://orcid.org/0000-0001-8092-1106
Funding Agency and Grant Number	Funding Agency Grant Number The LTx Unit at Hospital Israelita Albert Einstein is financed by the Programa de Apoio ao Desenvolvimento Insitucional do SUS (PROADI-SUS), a partnership with the Brazilian Ministry of Health 25000.171086/2023-80
Corresponding Author	Guilherme Felga, Assistant Professor, MD, PhD, Discipline of Gastroenterology, Department of Medicine, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Pedro de Toledo, 861/869, Sao Paulo 04039-032, Brazil. guilherme.felga@gmail.com
Key Words	Metabolic syndrome; Steatotic liver disease; Metabolic dysfunction-associated steatotic liver disease; Liver transplantation; Recurrence; Outcomes
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) is the fastest-growing indication for liver transplantation (LTx) in Western countries, and the recurrence rate approaches 100% at 5 years. Recurrent disease progresses faster than native liver MASLD and is driven by immunosuppression-mediated metabolic dysregulation. Immunosuppressive regimens may have limitations, and even though there is need for tailored strategies, evidence is lacking for their application in post-LTx MASLD. Histological assessment remains essential for risk stratification despite advances in noninvasive diagnostics. Optimized immunosuppression, metabolic control, and emerging therapies are key research priorities to improve outcomes. Standardized guidelines for post-LTx MASLD management are urgently needed.
Publish Date	2025-07-25 12:09
Citation	<p>Zatta R, Silva LSD, Felga G, Pimentel CFG. Are we standing on the shifting sands of post-transplant metabolic-associated steatotic liver disease? <i>World J Hepatol</i> 2025; 17(7): 107837</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i7/107837.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i7.107837

Full Article (PDF)	WJH-17-107837-with-cover.pdf
Manuscript File	107837_Auto_Edited_074317.docx
Answering Reviewers	107837-answering-reviewers.pdf
Audio Core Tip	107837-audio.mp3
Conflict-of-Interest Disclosure Form	107837-conflict-of-interest-statement.pdf
Copyright License Agreement	107837-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	107837-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	107837-non-native-speakers.pdf
Peer-review Report	107837-peer-reviews.pdf
Scientific Misconduct Check	107837-scientific-misconduct-check.png
Scientific Editor Work List	107837-scientific-editor-work-list.pdf
CrossCheck Report	107837-crosscheck-report.pdf