Publication Name	World Journal of Cardiology
Manuscript ID	107847
Country	China

Received	2025-04-02 06:53
Peer-Review Started	2025-04-02 06:53
To Make the First Decision
Return for Revision	2025-04-28 09:19
Revised	2025-05-12 09:20
Second Decision	2025-08-11 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-12 07:23
Articles in Press	2025-08-12 07:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-18 00:15
Publish the Manuscript Online	2025-08-21 08:16

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Relationship between genotype and clinical phenotype of hypertrophic cardiomyopathy
Manuscript Source	Invited Manuscript
All Author List	Lan-Lan Zhang, Bo Wang, Jing Wang, Jia Zhao and Li-Wen Liu
ORCID	Author(s) ORCID Number Lan-Lan Zhang http://orcid.org/0009-0003-7360-2037 Li-Wen Liu http://orcid.org/0000-0001-9838-5727
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China No. 82371974 and No. 82272009 National Natural Science Foundation of China (Key Program) No. 8223006
Corresponding Author	Li-Wen Liu, Chief Physician, Full Professor, Department of Ultrasound, Xijing Hypertrophic Cardiomyopathy Center, Fourth Military Medical University, No. 127 Changle West Road, Xi’an 710000, Shaanxi Province, China. liuliwen@fmmu.edu.cn
Key Words	Hypertrophic cardiomyopathy; Genotype; Phenotype; Sarcomere; Thick myofilament; Thin myofilament
Core Tip	The presence of sarcomere mutations makes the prognosis of hypertrophic cardiomyopathy (HCM) patients worse. Compared with the two most common thick myofilament genes, MYH7 carriers have an earlier onset of HCM. Compared with patients with thick myofilament gene mutations, patients with thin myofilament mutations have a worse prognosis. Among patients with thin myofilament gene mutations, TNNC1 positive probands have the worst prognosis. In this paper, the close relationship between HCM hypertrophy pattern and genetic variation was combed and insights were put forward, which provided a theoretical basis for genetic testing and personalized management of HCM patients.
Publish Date	2025-08-21 08:16
Citation	<p>Zhang LL, Wang B, Wang J, Zhao J, Liu LW. Relationship between genotype and clinical phenotype of hypertrophic cardiomyopathy. <i>World J Cardiol</i> 2025; 17(8): 107847</p>
URL	https://www.wjgnet.com/1949-8462/full/v17/i8/107847.htm
DOI	https://dx.doi.org/10.4330/wjc.v17.i8.107847

Full Article (PDF)	WJC-17-107847-with-cover.pdf
Manuscript File	107847_Auto_Edited_011435.docx
Answering Reviewers	107847-answering-reviewers.pdf
Audio Core Tip	107847-audio.m4a
Conflict-of-Interest Disclosure Form	107847-conflict-of-interest-statement.pdf
Copyright License Agreement	107847-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	107847-non-native-speakers.pdf
Peer-review Report	107847-peer-reviews.pdf
Scientific Misconduct Check	107847-scientific-misconduct-check.png
Scientific Editor Work List	107847-scientific-editor-work-list.pdf
CrossCheck Report	107847-crosscheck-report.pdf