BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/16/2014 1:19:00 PM | Browse: 1032 | Download: 982
|
Received |
|
2012-11-09 11:17 |
|
Peer-Review Started |
|
2012-11-10 16:10 |
|
To Make the First Decision |
|
2012-11-21 12:20 |
|
Return for Revision |
|
2013-01-05 09:39 |
|
Revised |
|
|
|
Second Decision |
|
2013-03-08 16:49 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Company Editor-in-Chief |
|
2013-03-09 06:03 |
|
Articles in Press |
|
|
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2013-04-01 09:27 |
|
Publish the Manuscript Online |
|
2013-04-14 19:05 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Hepatitis B virus induces expression of cholesterol metabolism-related genes via TLR2 in HepG2 cells
|
Manuscript Source |
Invited Manuscript |
All Author List |
Ying-Ju Li, Ping Zhu, Yu Liang, Wei-Guo Yin and Jian-Hua Xiao |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Youth Foundation of Hunan Provincial Education Department |
11B110 |
Graduate Innovation Project of Hunan Provincial Education Department |
CX2010B382 |
|
Corresponding Author |
Jian-Hua Xiao, Professor, Institute of Pathogenic Biology, University of South China, Hengyang 421001, Hunan Province, China. jhxiao223@163.com
|
Key Words |
Hepatitis B virus; Toll-like receptors; Low-density lipoprotein receptor; 3-hydroxy-3-methylglutharyl-coenzyme A reductase |
Core Tip |
This study investigated whether hepatitis B virus (HBV) exacerbates hepatic cholesterol accumulation and explored the underlying mechanisms. The authors found that adenovirus HBV increased low-density lipoprotein receptor and 3-hydroxy-3-methylglutharyl-coenzyme A reductase expression, resulting in exacerbated cholesterol accumulation in HepG2 cells, which was mediated via the toll-like receptor 2 pathway. These results may also have implications in the treatment of atherosclerosis.
|
Publish Date |
2013-04-14 19:05 |
Citation |
Li YJ, Zhu P, Liang Y, Yin WG, Xiao JH. Hepatitis B virus induces expression of cholesterol metabolism-related genes via TLR2 in HepG2 cells. World J Gastroenterol 2013; 19(14): 2262-2269 |
URL |
http://www.wjgnet.com/1007-9327/full/v19/i14/2262.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v19.i14.2262 |
© 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345