Publication Name	World Journal of Gastroenterology
Manuscript ID	1079
Country	China

Received	2012-11-09 11:17
Peer-Review Started	2012-11-10 16:10
To Make the First Decision	2012-11-21 12:20
Return for Revision	2013-01-05 09:39
Revised
Second Decision	2013-03-08 16:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-09 06:03
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-04-01 09:27
Publish the Manuscript Online	2013-04-14 19:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Hepatitis B virus induces expression of cholesterol metabolism-related genes via TLR2 in HepG2 cells
Manuscript Source	Invited Manuscript
All Author List	Ying-Ju Li, Ping Zhu, Yu Liang, Wei-Guo Yin and Jian-Hua Xiao
Funding Agency and Grant Number	Funding Agency Grant Number Youth Foundation of Hunan Provincial Education Department 11B110 Graduate Innovation Project of Hunan Provincial Education Department CX2010B382
Corresponding Author	Jian-Hua Xiao, Professor, Institute of Pathogenic Biology, University of South China, Hengyang 421001, Hunan Province, China. jhxiao223@163.com
Key Words	Hepatitis B virus; Toll-like receptors; Low-density lipoprotein receptor; 3-hydroxy-3-methylglutharyl-coenzyme A reductase
Core Tip	This study investigated whether hepatitis B virus (HBV) exacerbates hepatic cholesterol accumulation and explored the underlying mechanisms. The authors found that adenovirus HBV increased low-density lipoprotein receptor and 3-hydroxy-3-methylglutharyl-coenzyme A reductase expression, resulting in exacerbated cholesterol accumulation in HepG2 cells, which was mediated via the toll-like receptor 2 pathway. These results may also have implications in the treatment of atherosclerosis.
Publish Date	2013-04-14 19:05
Citation	Li YJ, Zhu P, Liang Y, Yin WG, Xiao JH. Hepatitis B virus induces expression of cholesterol metabolism-related genes via TLR2 in HepG2 cells. World J Gastroenterol 2013; 19(14): 2262-2269
URL	http://www.wjgnet.com/1007-9327/full/v19/i14/2262.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i14.2262

Full Article (PDF)	WJG-19-2262.pdf
Manuscript File	1079-Review.doc
Answering Reviewers	1079-Answering reviewers.pdf
Copyright License Agreement	1079-Copyright assignment.docx
Non-Native Speakers of English Editing Certificate	1079-Language certificate.doc
Peer-review Report	1079-Peer review(s).docx
Scientific Editor Work List	1079-Scientific editor work list.doc