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Articles Published Processes
9/26/2025 8:18:54 AM | Browse: 291 | Download: 93
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Received |
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2025-04-02 08:34 |
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Peer-Review Started |
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2025-04-03 01:45 |
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To Make the First Decision |
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Return for Revision |
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2025-04-23 11:22 |
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Revised |
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2025-05-07 00:05 |
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Second Decision |
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2025-07-23 02:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-23 07:38 |
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Articles in Press |
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2025-07-23 07:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-07-29 01:20 |
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Typeset the Manuscript |
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2025-09-06 14:51 |
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Publish the Manuscript Online |
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2025-09-26 08:18 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Glymphatic system dysfunction in alcohol use disorder: Current understanding and future directions
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia-Yu Lin, Hai-Bo Zhang, Ling Luo, Ren-Jie Li and Xiao-Guang Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Guang Wang, Associate Professor, MD, PhD, Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, No. 74 Zhongshan 2nd Road, Guangzhou 510080, Guangdong Province, China. wxguang@mail.sysu.edu.cn |
| Key Words |
Alcohol use disorder; Glymphatic system; Aquaporin 4; Perivascular space; Mitochondrial dysfunction |
| Core Tip |
The glymphatic system, a critical pathway for fluid exchange and waste clearance in the brain, is linked to neurological disorders when dysfunctional. Alcohol has a biphasic effect: Low doses enhance glymphatic function, while high doses suppress it and cause cognitive decline, mirroring alcohol-related dementia. Studies explore how alcohol affects cerebrospinal fluid-interstitial fluid exchange and waste removal. Despite progress, gaps remain in understanding mechanisms and confounding factors like gender, age, and blood pressure. The significance of this review lies in deepening the understanding of the relationship between alcohol and glymphatic system disorders and offering possible targets for developing new treatments. |
| Publish Date |
2025-09-26 08:18 |
| Citation |
<p>Lin JY, Zhang HB, Luo L, Li RJ, Wang XG. Glymphatic system dysfunction in alcohol use disorder: Current understanding and future directions. <i>World J Psychiatry</i> 2025; 15(10): 107936</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i10/107936.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i10.107936 |
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