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Articles Published Processes
8/12/2025 8:18:26 AM | Browse: 108 | Download: 451
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Received |
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2025-04-03 03:27 |
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Peer-Review Started |
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2025-04-11 08:56 |
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First Decision by Editorial Office Director |
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2025-05-01 02:45 |
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Return for Revision |
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2025-05-01 02:45 |
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Revised |
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2025-05-10 20:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-06-20 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-06-20 07:40 |
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Articles in Press |
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2025-06-20 07:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-04 01:51 |
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Publish the Manuscript Online |
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2025-08-12 08:18 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Observational Study |
| Article Title |
Circulating microRNAs and serum proteins in breast cancer patients: Diagnostic relevance and grade-specific expression patterns
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Safinaz E El‑Toukhy, Heba K Nabih, Mahmoud M Kamel, Hossam Elmasry and Sherien M El-Daly |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Centre, Egypt |
No. E120504 |
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| Corresponding Author |
Sherien M El-Daly, Professor, Department of Medical Biochemistry, Medical Research and Clinical Studies Institute, National Research Centre, 33 El Buhouth Street, Dokki, Giza 12622, Egypt. sm.el-daly@nrc.sci.eg |
| Key Words |
Breast cancer; Liquid biopsy; Tumor grading; MicroRNAs; Cancer antigen 15-3; 8-hydroxy-2′-deoxyguanosine; Sensitivity; Specificity |
| Core Tip |
This study highlights the diagnostic utility of a panel of circulating microRNAs (miRNAs), miR-21, miR-221, miR-1246, miR-145, and miR-382, in stratifying breast cancer patients by tumor grade. Notably, miR-21 and miR-1246 exhibited the highest diagnostic power in distinguishing patients from healthy controls. Importantly, integrating these miRNAs with traditional protein biomarkers cancer antigen 15-3 and 8-hydroxy-2′-deoxyguanosine significantly enhanced diagnostic accuracy and sensitivity, underscoring the value of a multi-marker approach for non-invasive breast cancer detection and grading. |
| Publish Date |
2025-08-12 08:18 |
| Citation |
El‑Toukhy SE, Nabih HK, Kamel MM, Elmasry H, El-Daly SM. Circulating microRNAs and serum proteins in breast cancer patients: Diagnostic relevance and grade-specific expression patterns. World J Exp Med 2025; 15(3): 108034 |
| URL |
https://www.wjgnet.com/2220-315X/full/v15/i3/108034.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i3.108034 |
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