Publication Name	World Journal of Diabetes
Manuscript ID	108101
Country	China

Received	2025-04-07 09:40
Peer-Review Started	2025-04-16 09:01
To Make the First Decision
Return for Revision	2025-04-24 02:46
Revised	2025-05-08 15:16
Second Decision	2025-06-17 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-02 09:11
Articles in Press	2025-07-02 09:11
Publication Fee Transferred	2025-05-10 16:23
Edit the Manuscript by Language Editor	2025-07-17 21:04
Typeset the Manuscript	2025-08-04 02:59
Publish the Manuscript Online	2025-08-14 10:52

ISSN	1948-9358 (online)
Open Access	Diabetic cystopathy (DCP), a debilitating complication of diabetes mellitus, involves hyperglycemia-driven bladder dysfunction. This study identified CREB3 L3 as a novel mediator of DCP pathogenesis. Chronic hyperglycemia induced CREB3 L3 overexpression in bladder urothelium, promoting C-reactive protein-dependent inflammation, epithelial-mesenchymal transition (EMT) and tight junction disruption. Silencing CREB3 L3 in SV-HUC-1 urothelial cells and a DCP rat model reversed EMT markers (downregulation of N-cadherin and upregulation of E-cadherin protein), restored barrier proteins (Occludin/Claudin1 protein), and attenuated bladder remodeling. These findings have established CREB3 L3 as a therapeutic target to preserve urothelial integrity and mitigate DCP progression.
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	Hyperglycemia-induced overexpression of CREB3 L3 promotes the epithelial-to-mesenchymal transition in bladder urothelial cells in diabetes mellitus
Manuscript Source	Unsolicited Manuscript
All Author List	Qing-Guo Wu, Ming-Jin Zhang, Yi-Bi Lan, Chun-Lei Ma and Wei-Jin Fu
ORCID	Author(s) ORCID Number Wei-Jin Fu http://orcid.org/0009-0004-1387-7159
Funding Agency and Grant Number	Funding Agency Grant Number GuangXi Natural Science Foundation 2024GXNSFAA010031
Corresponding Author	Wei-Jin Fu, Chief Physician, Department of Urology, The First Affiliated Hospital of GuangXi Medical University, No. 6 Shuangyong Road, Qinxiu District, Nanning 530022, Guangxi Zhuang Autonomous Region, China. fwjgxmu1978@163.com
Key Words	Hyperglycemia; Epithelial-mesenchymal transition; Diabetic cystopathy
Core Tip	Diabetic cystopathy (DCP), a debilitating complication of diabetes mellitus, involves hyperglycemia-driven bladder dysfunction. This study identified CREB3 L3 as a novel mediator of DCP pathogenesis. Chronic hyperglycemia induced CREB3 L3 overexpression in bladder urothelium, promoting C-reactive protein-dependent inflammation, epithelial-mesenchymal transition (EMT) and tight junction disruption. Silencing CREB3 L3 in SV-HUC-1 urothelial cells and a DCP rat model reversed EMT markers (downregulation of N-cadherin and upregulation of E-cadherin protein), restored barrier proteins (Occludin/Claudin1 protein), and attenuated bladder remodeling. These findings have established CREB3 L3 as a therapeutic target to preserve urothelial integrity and mitigate DCP progression.
Publish Date	2025-08-14 10:52
Citation	<p>Wu QG, Zhang MJ, Lan YB, Ma CL, Fu WJ. Hyperglycemia-induced overexpression of CREB3 L3 promotes the epithelial-to-mesenchymal transition in bladder urothelial cells in diabetes mellitus. <i>World J Diabetes</i> 2025; 16(8): 108101</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i8/108101.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i8.108101

Full Article (PDF)	WJD-16-108101-with-cover.pdf
The ARRIVE Guidelines	108101-The-ARRIVE-Guidelines.pdf
Manuscript File	108101_Auto_Edited_075349.docx
Answering Reviewers	108101-answering-reviewers.pdf
Audio Core Tip	108101-audio.mp3
Biostatistics Review Certificate	108101-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	108101-conflict-of-interest-statement.pdf
Copyright License Agreement	108101-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108101-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	108101-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	108101-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	108101-non-native-speakers.pdf
Peer-review Report	108101-peer-reviews.pdf
Scientific Editor Work List	108101-scientific-editor-work-list.pdf
CrossCheck Report	108101-crosscheck-report.pdf