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9/24/2025 9:02:03 AM | Browse: 65 | Download: 54
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 108127
Country Malaysia
Received
2025-04-08 15:18
Peer-Review Started
2025-04-08 15:18
To Make the First Decision
Return for Revision
2025-05-14 11:02
Revised
2025-05-27 09:46
Second Decision
2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-31 06:22
Articles in Press
2025-07-31 06:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-09-05 08:38
Publish the Manuscript Online
2025-09-24 09:02
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Randomized Controlled Trial
Article Title Effects of preoperative immunonutrition vs standard oral nutrition in patients undergoing colorectal surgery: A randomized controlled trial
Manuscript Source Invited Manuscript
All Author List Manivaasan Pannirselvam, Zaidi Zakaria, Michael Pak-Kai Wong, Mohd Hady Shukri Abdul Satar, Nor Syarahani Jusoh, Andee Dzulkarnaen Zakaria and Muhammad Faeid Othman
ORCID
Author(s) ORCID Number
Manivaasan Pannirselvam http://orcid.org/0000-0003-0980-8068
Zaidi Zakaria http://orcid.org/0000-0003-1644-3546
Michael Pak-Kai Wong http://orcid.org/0000-0001-9137-3096
Mohd Hady Shukri Abdul Satar http://orcid.org/0000-0003-2966-580X
Nor Syarahani Jusoh http://orcid.org/0009-0001-2105-2892
Andee Dzulkarnaen Zakaria http://orcid.org/0000-0002-4826-9725
Muhammad Faeid Othman http://orcid.org/0000-0002-7674-2663
Funding Agency and Grant Number
Funding Agency Grant Number
Universiti Sains Malaysia, Short-Term Grant R501-LR-RND002-0000000342-0000
Corresponding Author Muhammad Faeid Othman, MD, Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Jalan Raja Perempuan Zainab II, Kubang Kerian 16150, Kelantan, Malaysia. faeid@usm.my
Key Words Cancer surgery; Colorectal surgery; Gastrointestinal surgery; Immunonutrition; Postoperative complication
Core Tip This randomized controlled trial evaluated the effects of preoperative immunonutrition vs standard oral nutrition supplements in patients undergoing colorectal surgery. Despite theoretical benefits, immunonutrition did not significantly improve postoperative gastrointestinal recovery, reduce infectious complications, or shorten hospital stay. All baseline and surgical variables were comparable between groups. The findings suggest that routine use of immunonutrition may not confer additional clinical advantages over standard supplementation in this patient population, challenging current recommendations and supporting a more individualized nutritional approach.
Publish Date 2025-09-24 09:02
Citation <p>Pannirselvam M, Zakaria Z, Wong MPK, Abdul Satar MHS, Jusoh NS, Zakaria AD, Othman MF. Effects of preoperative immunonutrition vs standard oral nutrition in patients undergoing colorectal surgery: A randomized controlled trial. <i>World J Gastrointest Surg</i> 2025; 17(9): 108127</p>
URL https://www.wjgnet.com/1948-9366/full/v17/i9/108127.htm
DOI https://dx.doi.org/10.4240/wjgs.v17.i9.108127
Full Article (PDF) WJGS-17-108127-with-cover.pdf
CONSORT 2010 Statement 108127-CONSORT-2010-statement.pdf
Manuscript File 108127_Auto_Edited_064106.docx
Answering Reviewers 108127-answering-reviewers.pdf
Audio Core Tip 108127-audio.m4a
Biostatistics Review Certificate 108127-biostatistics-statement.pdf
Clinical Trial Registration Statement 108127-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 108127-conflict-of-interest-statement.pdf
Copyright License Agreement 108127-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 108127-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 108127-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 108127-non-native-speakers.pdf
Peer-review Report 108127-peer-reviews.pdf
Scientific Misconduct Check 108127-scientific-misconduct-check.png
Scientific Editor Work List 108127-scientific-editor-work-list.pdf
CrossCheck Report 108127-crosscheck-report.pdf