BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/18/2025 9:55:57 AM | Browse: 371 | Download: 82
 |
Received |
|
2025-04-07 10:55 |
|
Peer-Review Started |
|
2025-04-07 10:56 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2025-05-27 19:17 |
|
Revised |
|
2025-06-14 15:34 |
|
Second Decision |
|
2025-08-06 02:35 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2025-08-06 08:57 |
|
Articles in Press |
|
2025-08-06 08:57 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-09-01 05:53 |
|
Publish the Manuscript Online |
|
2025-09-18 09:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Reem S Alruhaimi, Emad H M Hassanein, Sulaiman M Alnasser, Ahmad F Ahmeda, Hanan S Althagafy, Omnia A M Abd El-Ghafar and Ayman M Mahmoud |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Princess Nourah bint Abdulrahman University Researchers Supporting Project Number (PNURSP2025R381), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia |
|
|
| Corresponding Author |
Ayman M Mahmoud, Professor, Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Dalton Building, Manchester M1 5GD, United Kingdom. a.mahmoud@mmu.ac.uk |
| Key Words |
Chemotherapy; Ambroxol; Oxidative stress; Inflammation; Hepatotoxicity; Cyclophosphamide; Acute liver injury |
| Core Tip |
Cyclophosphamide (CP) is a cornerstone chemotherapeutic and immunosuppressive agent, but its hepatotoxicity limits its clinical utility. While oxidative stress and inflammation are known contributors to CP-induced liver injury, effective therapeutic strategies to counteract these effects remain limited. This study is the first to demonstrate that ambroxol exerts potent hepatoprotective effects against CP hepatotoxicity. Our findings not only elucidate the molecular mechanisms underlying the hepatoprotective effects of ambroxol but also position it as a promising adjunct therapy to mitigate CP hepatotoxicity. Given the lack of effective hepatoprotective agents against CP toxicity, this study has significant translational implications. |
| Publish Date |
2025-09-18 09:55 |
| Citation |
<p>Alruhaimi RS, Hassanein EHM, Alnasser SM, Ahmeda AF, Althagafy HS, Abd El-Ghafar OAM, Mahmoud AM. Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1. <i>World J Gastroenterol</i> 2025; 31(35): 108139</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i35/108139.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i35.108139 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
