Publication Name	World Journal of Diabetes
Manuscript ID	108166
Country	China

Received	2025-04-07 09:46
Peer-Review Started	2025-04-12 03:01
To Make the First Decision
Return for Revision	2025-05-12 04:40
Revised	2025-05-20 09:41
Second Decision	2025-06-17 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-02 01:01
Articles in Press	2025-07-02 01:01
Publication Fee Transferred	2025-05-26 12:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-01 13:15
Publish the Manuscript Online	2025-08-14 10:51

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	Diabetic foot ulcers (DFUs) are a prevalent and significant complication of diabetes, characterized by slow wound healing and an increased risk of infection. These infections severely impact patient health, often requiring extensive medical intervention and increasing the risk of amputation. Vitamin D plays a critical role in immune regulation and wound healing. This study found that Vitamin D supplementation effectively reduced infection rates, enhanced wound healing, and strengthened immune responses in DFU cases. These findings suggest that Vitamin D is a beneficial and safe adjunct to standard DFU care, potentially mitigating infection-related complications and improving clinical outcomes.
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Randomized Controlled Trial
Article Title	Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers
Manuscript Source	Unsolicited Manuscript
All Author List	Yue-Qiao Gao, Ying-Hui Gao and Jun-Hui Xing
ORCID	Author(s) ORCID Number Jun-Hui Xing http://orcid.org/0000-0001-9130-7865
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Henan Province 202300410396 Young Talents Promotion Project of Henan Province 2021HYTP043
Corresponding Author	Jun-Hui Xing, MD, PhD, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Eastern Road, Zhengzhou 450000, Henan Province, China. xjunhui404@163.com
Key Words	Vitamin D; Diabetic foot ulcers; Infection rate; Wound healing; Immune response; Cathelicidin; Inflammation; Randomized controlled trial
Core Tip	Diabetic foot ulcers (DFUs) are a prevalent and significant complication of diabetes, characterized by slow wound healing and an increased risk of infection. These infections severely impact patient health, often requiring extensive medical intervention and increasing the risk of amputation. Vitamin D plays a critical role in immune regulation and wound healing. This study found that Vitamin D supplementation effectively reduced infection rates, enhanced wound healing, and strengthened immune responses in DFU cases. These findings suggest that Vitamin D is a beneficial and safe adjunct to standard DFU care, potentially mitigating infection-related complications and improving clinical outcomes.
Publish Date	2025-08-14 10:51
Citation	<p>Gao YQ, Gao YH, Xing JH. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers. <i>World J Diabetes</i> 2025; 16(8): 108166</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i8/108166.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i8.108166

Full Article (PDF)	WJD-16-108166-with-cover.pdf
CONSORT 2010 Statement	108166-CONSORT-2010-statement.pdf
Manuscript File	108166_Auto_Edited_013924.docx
Answering Reviewers	108166-answering-reviewers.pdf
Audio Core Tip	108166-audio.m4a
Biostatistics Review Certificate	108166-biostatistics-statement.pdf
Clinical Trial Registration Statement	108166-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	108166-conflict-of-interest-statement.pdf
Copyright License Agreement	108166-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108166-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	108166-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	108166-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	108166-non-native-speakers.pdf
Peer-review Report	108166-peer-reviews.pdf
Journal Editor-in-Chief Review Report	108166-journal-editor-in-chief.pdf
Scientific Editor Work List	108166-scientific-editor-work-list.pdf
CrossCheck Report	108166-crosscheck-report.pdf