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Articles Published Processes
12/19/2025 8:32:36 AM | Browse: 6 | Download: 45
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Received |
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2025-04-07 15:04 |
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Peer-Review Started |
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2025-04-11 00:48 |
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First Decision by Editorial Office Director |
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2025-05-07 02:07 |
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Return for Revision |
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2025-05-07 02:07 |
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Revised |
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2025-05-16 17:47 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-08-04 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-04 10:30 |
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Articles in Press |
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2025-08-04 10:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-02 02:40 |
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Publish the Manuscript Online |
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2025-12-19 08:32 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Proneurogenic and microglial modulatory properties of botulinum neurotoxin in the hippocampus of aging experimental mice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jerly Helan Mary Joseph, Mercy Priyadharshini Babu Deva Irakkam and Mahesh Kandasamy |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Science and Engineering Research Board (SERB), No. SERB-EEQ/2016/000639 and RUSA 2.0, Biological Sciences, Bharathidasan University, No. TN RUSA: 311/RUSA (2.0)/2018 dt. 2 December 2020 |
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| Kandasamy M has been supported by the Faculty Recharge Programme, University Grants Commission (UGC-FRP), New Delhi, India |
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| Corresponding Author |
Mahesh Kandasamy, Assistant Professor, PhD, Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India. mahesh.kandasamy@bdu.ac.in |
| Key Words |
Botulinum neurotoxin; Doublecortin; Microglia; Neurogenesis; Cyclooxygenase; Nitric oxide; Hippocampus |
| Core Tip |
Botulinum neurotoxin (BoNT) exerts pleiotropic effects, including notable neuroprotection. This study evaluated whether BoNT can ameliorate aging-related neuroinflammation and prevent the decline of hippocampal neurogenesis. BoNT treatment significantly reduced the number of activated microglia, accompanied by decreased expression of cyclooxygenase-2 and diminished levels of nitric oxide. Therefore, the observed increase in doublecortin-positive immature neurons and bromodeoxyuridine - neuronal nuclei double-positive newly generated neurons in the hippocampus may signify the synergistic anti-inflammatory and neuroregenerative properties of BoNT. These findings suggest that BoNT treatment could be explored as a therapeutic agent for the treatment of dementia. |
| Publish Date |
2025-12-19 08:32 |
| Citation |
Joseph JHM, Babu Deva Irakkam MP, Kandasamy M. Proneurogenic and microglial modulatory properties of botulinum neurotoxin in the hippocampus of aging experimental mice. World J Exp Med 2025; 15(4): 108187 |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i4/108187.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i4.108187 |
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