Publication Name	World Journal of Psychiatry
Manuscript ID	108222
Country	Germany

Received	2025-04-08 13:54
Peer-Review Started	2025-04-09 02:40
To Make the First Decision
Return for Revision	2025-04-30 07:32
Revised	2025-05-13 20:13
Second Decision	2025-07-23 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-23 07:23
Articles in Press	2025-07-23 07:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-14 09:19
Publish the Manuscript Online	2025-08-26 10:18

ISSN	2220-3206 (online)
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Category	Genetics & Heredity
Manuscript Type	Letter to the Editor
Article Title	Unmet needs in precision psychiatry
Manuscript Source	Unsolicited Manuscript
All Author List	Philipp G Sand, Timm B Poeppl and Vera Roessler
ORCID	Author(s) ORCID Number Philipp G Sand http://orcid.org/0000-0001-5806-5841 Timm B Poeppl http://orcid.org/0000-0002-5992-5695
Funding Agency and Grant Number
Corresponding Author	Philipp G Sand, Associate Professor, MD, Department of Psychiatry, University of Regensburg, Universitätsstr. 84, Regensburg 93053, Bavaria, Germany. philipp.sand@ukr.de
Key Words	Major depressive disorder; Antidepressant efficacy; Meta-analysis; 5-HTR1A gene; C-1019G polymorphism
Core Tip	A recent meta-analysis has suggested a 5-HTR1A promoter variant may predict antidepressant response. However, re-analysis of the original data unveiled numerous shortcomings pertaining to genetic exposure and interpretation of genetic findings. We alert to ambiguities that are likely to have introduced bias in the calculation of overall effects by muddling of alleles or entire genes, and by demographic inaccuracies. In part, these may be explained by specific features of genetic information that are not encoded in the DNA sequence, such as transcriptional orientation.
Publish Date	2025-08-26 10:18
Citation	<p>Sand PG, Poeppl TB, Roessler V. Unmet needs in precision psychiatry. <i>World J Psychiatry</i> 2025; 15(9): 108222</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i9/108222.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i9.108222

Full Article (PDF)	WJP-15-108222-with-cover.pdf
Manuscript File	108222_Auto_Edited_020226.docx
Answering Reviewers	108222-answering-reviewers.pdf
Audio Core Tip	108222-audio.m4a
Conflict-of-Interest Disclosure Form	108222-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	108222-non-native-speakers.pdf
Peer-review Report	108222-peer-reviews.pdf
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Scientific Editor Work List	108222-scientific-editor-work-list.pdf
CrossCheck Report	108222-crosscheck-report.pdf