Publication Name	World Journal of Gastroenterology
Manuscript ID	108234
Country	Australia

Received	2025-04-09 00:42
Peer-Review Started	2025-04-09 00:42
To Make the First Decision
Return for Revision	2025-04-21 18:43
Revised	2025-05-04 23:53
Second Decision	2025-06-04 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-04 07:04
Articles in Press	2025-06-04 07:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-24 00:39
Publish the Manuscript Online	2025-06-26 07:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Sarah Schulze, Sahar Keshvari, Gregory C Miller, Kim R Bridle, David A Hume and Katharine M Irvine
ORCID	Author(s) ORCID Number Sarah Schulze http://orcid.org/0000-0002-9140-8276 Sahar Keshvari http://orcid.org/0000-0002-8116-8889 David A Hume http://orcid.org/0000-0002-2615-1478 Katharine M Irvine http://orcid.org/0000-0002-6716-1605
Funding Agency and Grant Number	Funding Agency Grant Number the German Research Foundation (Deutsche Forschungsgemeinschaft) the Australian National Health and Medical Research Council and the Mater Foundation
Corresponding Author	Katharine M Irvine, Associate Professor, PhD, Translational Research Institute, Mater Research Institute-University of Queensland, 37 Kent Street, Woolloongabba, Brisbane 4102, Queensland, Australia. katharine.irvine@uq.edu.au
Key Words	Macrophages; Ischaemia; Necrosis; Liver; Hepatectomy; Innate immunity; Regeneration
Core Tip	During liver surgery, temporary interruption of blood flow followed by reperfusion can lead to tissue damage and inflammation. Macrophages and recruited monocytes can contribute to tissue damage and inflammation, but they are also necessary for injury resolution and prevention of post-operative infections. We show that perisurgical administration of the macrophage growth factor colony stimulating factor 1 promotes the accumulation of CD163+ pro-regenerative macrophages, reduces ischemia reperfusion-induced necrosis, and promotes liver growth in rats.
Publish Date	2025-06-26 07:56
Citation	<p>Schulze S, Keshvari S, Miller GC, Bridle KR, Hume DA, Irvine KM. Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats. <i>World J Gastroenterol</i> 2025; 31(24): 108234</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i24/108234.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i24.108234

Full Article (PDF)	WJG-31-108234-with-cover.pdf
The ARRIVE Guidelines	108234-The-ARRIVE-Guidelines.pdf
Manuscript File	108234_Auto_Edited_055219.docx
Answering Reviewers	108234-answering-reviewers.pdf
Audio Core Tip	108234-audio.m4a
Biostatistics Review Certificate	108234-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	108234-conflict-of-interest-statement.pdf
Copyright License Agreement	108234-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108234-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	108234-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	108234-institutional-review-board-statement.pdf
Supplementary Material	108234-supplementary-material.pdf
Peer-review Report	108234-peer-reviews.pdf
Scientific Misconduct Check	108234-scientific-misconduct-check.png
Scientific Editor Work List	108234-scientific-editor-work-list.pdf
CrossCheck Report	108234-crosscheck-report.pdf