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Articles Published Processes
10/24/2025 7:36:24 AM | Browse: 218 | Download: 420
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Received |
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2025-06-05 09:08 |
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Peer-Review Started |
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2025-06-05 09:08 |
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First Decision by Editorial Office Director |
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2025-07-08 05:39 |
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Return for Revision |
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2025-07-08 05:39 |
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Revised |
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2025-07-22 07:30 |
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Publication Fee Transferred |
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2025-07-28 07:40 |
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Second Decision by Editor |
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2025-08-18 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-18 06:34 |
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Articles in Press |
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2025-08-18 06:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-10 07:04 |
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Publish the Manuscript Online |
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2025-10-24 07:36 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Compound spleen-tonifying composition alleviates dextran sulfate sodium-induced ulcerative colitis in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Cui Zhao, Qing-Lan Zhao, Yan Zhang, Nan Zhao, Jia-Qi Tian, Yan-Yun Wu and Wei Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jilin Province Science and Technology Development Plan Project |
20210204012YY |
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| Corresponding Author |
Yan-Yun Wu, Quality Management Department, The 964th Hospital of the Joint Logistics Support Force, No. 4799 Xi'an Road, Lvyuan District, Changchun 130062, Jilin Province, China. wyy964yy@163.com |
| Key Words |
Ulcerative colitis; Compound spleen-tonifying composition; Dextran sulfate sodium; Oxidative stress; Inflammation |
| Core Tip |
This study reveals that the compound spleen-tonifying composition (CSTC), a traditional Chinese medicine formula, alleviates ulcerative colitis (UC) through dual modulation of oxidative stress, inflammation and tight junction protein expression. Crucially, bioactivity is polarity-dependent: Polar solvent extracts (ethyl acetate/n-butanol) show superior efficacy to non-polar extracts in restoring intestinal barrier integrity, reducing dextran sulfate sodium-induced damage, and normalizing inflammatory/oxidative markers. This is the first report establishing extraction methodology as a critical determinant of CSTC’s therapeutic effects, providing a novel strategy for optimizing herbal formulations against UC. |
| Publish Date |
2025-10-24 07:36 |
| Citation |
Zhao WC, Zhao QL, Zhang Y, Zhao N, Tian JQ, Wu YY, Zhang W. Compound spleen-tonifying composition alleviates dextran sulfate sodium-induced ulcerative colitis in rats. World J Gastrointest Surg 2025; 17(10): 108239 |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i10/108239.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i10.108239 |
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