BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/4/2025 7:48:05 AM | Browse: 298 | Download: 31
 |
Received |
|
2025-04-09 09:20 |
|
Peer-Review Started |
|
2025-04-09 09:21 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2025-04-28 09:21 |
|
Revised |
|
2025-05-06 19:09 |
|
Second Decision |
|
2025-07-17 02:42 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2025-07-17 07:56 |
|
Articles in Press |
|
2025-07-17 07:56 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-08-27 07:59 |
|
Publish the Manuscript Online |
|
2025-09-04 07:48 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Odevixibat improves pruritus and bile acid level in Alagille syndrome: A case report
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Eman Al Atrash and Rana Bitar |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Rana Bitar, Assistant Professor, Division of Pediatric Gastroenterology, Sheikh Khalifa Medical City, Al Karamah Street, Abu Dhabi 51900, United Arab Emirates. rahmad@seha.ae |
| Key Words |
Alagille syndrome; Liver; Ileal bile acid transporter inhibitor; Cholestasis; pruritus; Case report |
| Core Tip |
Alagille syndrome is a rare genetic disorder that affects the liver causing, cholestasis, jaundice and intractable pruritus which can significantly impair health-related quality of life. The treatment is mainly supportive with majority eventually requiring liver transplant. Ileal bile acid transporter inhibition is a novel therapeutic concept for cholestatic pruritus and cholestatic liver disease. We report the effects of odevixibat treatment in a patient Alagille syndrome over 12 months. This case demonstrates the use of ileal bile acid transporter inhibitors treating pruritus and improving patient quality of life and biochemical parameters. This allowed for the delay in the need for liver transplantation. It has potential to delay the need for liver transplantation. However more long-term studies are needed to help clinicians better understand the benefit of this new treatment. |
| Publish Date |
2025-09-04 07:48 |
| Citation |
<p>Al Atrash E, Bitar R. Odevixibat improves pruritus and bile acid level in Alagille syndrome: A case report. <i>World J Gastrointest Pharmacol Ther</i> 2025; 16(3): 108257</p> |
| URL |
https://www.wjgnet.com/2150-5349/full/v16/i3/108257.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v16.i3.108257 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
