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Articles Published Processes
8/20/2025 8:41:22 AM | Browse: 36 | Download: 19
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Received |
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2025-04-10 07:15 |
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Peer-Review Started |
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2025-04-10 07:15 |
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To Make the First Decision |
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Return for Revision |
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2025-04-28 09:18 |
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Revised |
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2025-05-08 08:51 |
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Second Decision |
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2025-06-30 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-30 10:46 |
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Articles in Press |
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2025-06-30 10:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-07 02:36 |
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Publish the Manuscript Online |
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2025-08-20 08:41 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Editorial |
| Article Title |
Rosmarinic acid as a chemosensitizer in colorectal cancer: Targeting nuclear factor-kappa B pathway to overcome chemoresistance
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yun-Yun Xu, Wen-Jing Chen, Yu-Jie Cai, Feng Lin and Zhi-Peng He |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhi-Peng He, MD, PhD, Visiting Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230000, Anhui Province, China. hezhipeng0901@163.com |
| Key Words |
Rosmarinic acid; Colorectal cancer; Nuclear factor-kappa B signaling; Chemoresistance; Chemosensitizer; Natural products |
| Core Tip |
This study demonstrates that rosmarinic acid (RA), a natural polyphenol, suppresses colorectal cancer progression by inhibiting nuclear factor-kappa B signaling and synergizes with chemotherapeutics (5-fluorouracil/oxaliplatin) to overcome drug resistance. RA’s dual role as a cytotoxic agent and chemosensitizer highlights its potential in precision oncology. While in vitro findings are promising, future research must address RA’s bioavailability, in vivo efficacy, and clinical safety to translate this natural compound into actionable colorectal cancer therapies. |
| Publish Date |
2025-08-20 08:41 |
| Citation |
<p>Xu YY, Chen WJ, Cai YJ, Lin F, He ZP. Rosmarinic acid as a chemosensitizer in colorectal cancer: Targeting nuclear factor-kappa B pathway to overcome chemoresistance. <i>World J Clin Oncol</i> 2025; 16(8): 108279</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i8/108279.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i8.108279 |
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