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Articles Published Processes
8/14/2025 10:52:02 AM | Browse: 7 | Download: 27
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Received |
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2025-04-11 09:09 |
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Peer-Review Started |
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2025-04-22 09:05 |
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To Make the First Decision |
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Return for Revision |
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2025-05-17 14:46 |
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Revised |
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2025-05-19 06:39 |
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Second Decision |
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2025-07-14 02:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-14 09:01 |
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Articles in Press |
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2025-07-14 09:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-04 03:10 |
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Publish the Manuscript Online |
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2025-08-14 10:52 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Chemistry, Medicinal |
| Manuscript Type |
Editorial |
| Article Title |
Rheb1 as a novel β-cell regulator connecting mTORC1, AMPK, and NOTCH1 pathways for efficient diabetes therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mostafa M Gouda |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang University Global Partnership Fund |
BIO-0322023 |
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| Corresponding Author |
Mostafa M Gouda, PhD, Professor, Department of Biosystem Engineering and Food Science, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310027, Zhejiang Province, China. mostafa-gouda@zju.edu.cn |
| Key Words |
Ras homolog enriched in brain 1; Β-cell proliferation; Maturity-onset diabetes of the young 1; Diabetes therapy; Metabolic regulation; Pancreatic islets; Insulin secretion |
| Core Tip |
This editorial emphasizes the critical role of β-cells in diabetes risk, particularly regarding brain dysfunction and ulceration in young individuals, and underscores the need for further investigation. Recent studies, including that of Yang et al, demonstrate the key influence of Ras homolog enriched in brain 1 on β-cell function and proliferation, which is linked to insulin secretion and glucose levels. This suggests that Ras homolog enriched in brain 1 influences the mammalian target of rapamycin complex 1 and AMP-activated protein kinase pathways, confirming the existence of the islet reflex instead of relying solely on one pathway. This metabolic role opens up therapeutic avenues for advanced treatment targets of diabetes-related brain dysfunction. |
| Publish Date |
2025-08-14 10:52 |
| Citation |
<p>Gouda MM. Rheb1 as a novel β-cell regulator connecting mTORC1, AMPK, and NOTCH1 pathways for efficient diabetes therapy. <i>World J Diabetes</i> 2025; 16(8): 108310</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i8/108310.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i8.108310 |
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