Publication Name	World Journal of Gastroenterology
Manuscript ID	108321
Country	China

Received	2025-04-18 02:44
Peer-Review Started	2025-04-18 02:44
To Make the First Decision
Return for Revision	2025-04-29 02:29
Revised	2025-05-12 12:52
Second Decision	2025-07-02 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-02 06:01
Articles in Press	2025-07-02 06:01
Publication Fee Transferred	2025-05-17 05:41
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-22 03:39
Publish the Manuscript Online	2025-07-24 07:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medical Laboratory Technology
Manuscript Type	Observational Study
Article Title	Construction of a community-based primary screening and hospital-based confirmatory screening pathway in pediatric nonalcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ming-Jie Yao, Yun-Fei Xing, Shu-Hong Liu, Ya-Fei Peng, Shu-Han Yang, Juan-Juan Chen, Jing-Min Zhao and Hui Wang
ORCID	Author(s) ORCID Number Jing-Min Zhao http://orcid.org/0000-0003-4345-2149 Hui Wang http://orcid.org/0000-0002-7639-5702
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82272433 Fujian Provincial Key Laboratory of Hepatic Drug Research 2022-YF-0050 Major Science and Technology Projects for Health of Zhejiang Province WKJ-ZJ-2216 Cyrus Tang Foundation for Young Scholar 2022 (2022-B126)
Corresponding Author	Hui Wang, Assistant Professor, PhD, Department of Maternal and Child Health, Peking University Health Science Center, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China. huiwang@bjmu.edu.cn
Key Words	Children; Nonalcoholic fatty liver disease; Significant fibrosis; Machine learning; Less invasive test
Core Tip	Fibrosis is a critical event in the progression of pediatric nonalcoholic fatty liver disease (NAFLD), and practical and efficient screening indices for early detection and referral in a large population are urgently needed. Different indices were generated for tertiary hospitals and community health centers based on the data of Chinese NAFLD children individually confirmed via liver biopsy. Serial tests were able to dramatically increase the positive predictive value. The sequential implementation of these less invasive screening predictors and referral systems could help physicians in accurately detecting the risk population accurately; however, broad age/ethnic range population validation is needed.
Publish Date	2025-07-24 07:47
Citation	<p>Yao MJ, Xing YF, Liu SH, Peng YF, Yang SH, Chen JJ, Zhao JM, Wang H. Construction of a community-based primary screening and hospital-based confirmatory screening pathway in pediatric nonalcoholic fatty liver disease. <i>World J Gastroenterol</i> 2025; 31(28): 108321</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i28/108321.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i28.108321

Full Article (PDF)	WJG-31-108321-with-cover.pdf
STROBE Statement	108321-STROBE-statement.pdf
Manuscript File	108321_Auto_Edited_014537.docx
Answering Reviewers	108321-answering-reviewers.pdf
Audio Core Tip	108321-audio.m4a
Biostatistics Review Certificate	108321-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	108321-conflict-of-interest-statement.pdf
Copyright License Agreement	108321-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108321-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	108321-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	108321-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	108321-non-native-speakers.pdf
Supplementary Material	108321-supplementary-material.pdf
Peer-review Report	108321-peer-reviews.pdf
Scientific Misconduct Check	108321-scientific-misconduct-check.png
Scientific Editor Work List	108321-scientific-editor-work-list.pdf
CrossCheck Report	108321-crosscheck-report.pdf