Publication Name	World Journal of Diabetes
Manuscript ID	108344
Country	South Korea

Received	2025-04-13 11:40
Peer-Review Started	2025-04-16 07:38
To Make the First Decision
Return for Revision	2025-05-07 03:49
Revised	2025-05-19 07:20
Second Decision	2025-06-16 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-23 09:37
Articles in Press	2025-06-23 09:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-03 00:37
Publish the Manuscript Online	2025-07-15 08:26

ISSN	1948-9358 (online)
Open Access	This large-scale nationwide cohort study explored the association between exercise intensity and the risk of end-stage renal disease (ESRD) in patients with diabetes. The findings indicate that high-intensity physical activity (≥ 1500 metabolic equivalents of task-min/week) significantly reduced ESRD risk, particularly in those with diabetes for over 10 years. Subgroup analyses revealed the greatest benefit in patients without hypertension, non-smokers, and those with higher body mass index. These findings highlight the potential of targeted exercise interventions to delay renal complications in diabetes management.
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Health Care Sciences & Services
Manuscript Type	Retrospective Cohort Study
Article Title	Exercise intensity and the risk of end-stage renal disease in diabetes: A nationwide population-based study
Manuscript Source	Unsolicited Manuscript
All Author List	Eun Hui Bae, Sang Yup Lim, Bong-Seong Kim, Kyung-Do Han, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma and Soo Wan Kim
ORCID	Author(s) ORCID Number Eun Hui Bae http://orcid.org/0000-0003-1727-2822 Bong-Seong Kim http://orcid.org/0000-0002-1022-3553 Kyung-Do Han http://orcid.org/0000-0002-9622-0643 Sang Heon Suh http://orcid.org/0000-0003-3076-3466 Hong Sang Choi http://orcid.org/0000-0001-8191-4071 Chang Seong Kim http://orcid.org/0000-0001-8753-7641 Seong Kwon Ma http://orcid.org/0000-0002-5758-8189 Soo Wan Kim http://orcid.org/0000-0002-3540-9004
Funding Agency and Grant Number	Funding Agency Grant Number the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) RS-2023-00217317 Chonnam National University Grant 2024-0444-01 the Chonnam National University Hospital Institute for Biomedical Science BCRI24032
Corresponding Author	Soo Wan Kim, MD, PhD, Professor, Department of Internal Medicine, Chonnam National University Medical School, Jebongro 42, Gwangju 61469, South Korea. skimw@chonnam.ac.kr
Key Words	Exercise; Diabetes mellitus; End-stage renal disease; Chronic kidney disease; Intensity; Duration
Core Tip	This large-scale nationwide cohort study explored the association between exercise intensity and the risk of end-stage renal disease (ESRD) in patients with diabetes. The findings indicate that high-intensity physical activity (≥ 1500 metabolic equivalents of task-min/week) significantly reduced ESRD risk, particularly in those with diabetes for over 10 years. Subgroup analyses revealed the greatest benefit in patients without hypertension, non-smokers, and those with higher body mass index. These findings highlight the potential of targeted exercise interventions to delay renal complications in diabetes management.
Publish Date	2025-07-15 08:26
Citation	<p>Bae EH, Lim SY, Kim BS, Han KD, Suh SH, Choi HS, Kim CS, Ma SK, Kim SW. Exercise intensity and the risk of end-stage renal disease in diabetes: A nationwide population-based study. <i>World J Diabetes</i> 2025; 16(7): 108344</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i7/108344.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i7.108344

Full Article (PDF)	WJD-16-108344-with-cover.pdf
STROBE Statement	108344-STROBE-statement.pdf
Manuscript File	108344_Auto_Edited_072416.docx
Answering Reviewers	108344-answering-reviewers.pdf
Audio Core Tip	108344-audio.mp3
Biostatistics Review Certificate	108344-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	108344-conflict-of-interest-statement.pdf
Copyright License Agreement	108344-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108344-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	108344-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	108344-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	108344-non-native-speakers.pdf
Supplementary Material	108344-supplementary-material.pdf
Peer-review Report	108344-peer-reviews.pdf
Journal Editor-in-Chief Review Report	108344-journal-editor-in-chief.pdf
Scientific Editor Work List	108344-scientific-editor-work-list.pdf
CrossCheck Report	108344-crosscheck-report.pdf