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Articles Published Processes
7/11/2025 7:47:42 AM | Browse: 8 | Download: 36
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Received |
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2025-04-12 08:57 |
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Peer-Review Started |
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2025-04-12 08:57 |
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To Make the First Decision |
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Return for Revision |
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2025-04-23 01:27 |
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Revised |
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2025-05-01 17:00 |
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Second Decision |
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2025-06-27 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-27 06:40 |
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Articles in Press |
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2025-06-27 06:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-04 06:05 |
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Publish the Manuscript Online |
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2025-07-11 07:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Ulcerative colitis: Timeline to a cure
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jay Pravda |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jay Pravda, Department of Disease Pathogenesis, Inflammatory Disease Research Centre, 4371 Northlake Blvd No. 247, Palm Beach Gardens, FL 33410, United States. jay.pravda@protonmail.com |
| Key Words |
Ulcerative colitis; Pathogenesis; Treatment; Hydrogen peroxide; Common pathway |
| Core Tip |
Since the mid-20th century, research into the causes of ulcerative colitis has predominantly focused on the immune system and microbiome, overlooking the colonic epithelium’s role in its pathogenesis. This conformation bias has delayed recognition of the causal role played by colonocyte hydrogen peroxide in the pathogenesis of this inflammatory bowel disease. Notably, fewer than a dozen studies since that time have laid the groundwork for this conclusion. This review critically examines these foundational studies through the lens of contemporary biomedical science, tracing their evolution toward the identification of a causal role for colonocyte hydrogen peroxide in the pathogenesis of ulcerative colitis. |
| Publish Date |
2025-07-11 07:47 |
| Citation |
<p>Pravda J. Ulcerative colitis: Timeline to a cure. <i>World J Gastroenterol</i> 2025; 31(26): 108375</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i26/108375.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i26.108375 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
