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Articles Published Processes
8/26/2025 10:18:28 AM | Browse: 108 | Download: 230
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Received |
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2025-05-09 08:05 |
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Peer-Review Started |
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2025-05-09 08:05 |
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First Decision by Editorial Office Director |
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2025-05-30 01:59 |
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Return for Revision |
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2025-05-30 01:59 |
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Revised |
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2025-06-12 14:15 |
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Publication Fee Transferred |
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2025-06-18 09:52 |
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Second Decision by Editor |
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2025-07-17 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-07-17 06:25 |
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Articles in Press |
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2025-07-17 06:25 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-14 03:51 |
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Publish the Manuscript Online |
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2025-08-26 10:18 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychology, Clinical |
| Manuscript Type |
Review |
| Article Title |
Modulating nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 in liver-brain axis disorders
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Ming Zhang and Zhi-Gang Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhi-Gang Zhang, General Practice Clinic Ward, Second Department of The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. m18098875906@163.com |
| Key Words |
Nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway; Liver-brain axis dysfunction; Hepatic encephalopathy; Cognitive impairment; Depression; Anxiety |
| Core Tip |
This study explores the critical role of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway in mitigating liver-brain axis dysfunction. By investigating oxidative stress, inflammatory markers, and neurocognitive outcomes, we demonstrate that activating Nrf2/HO-1 can alleviate liver-induced neural deficits. Using both in vitro and in vivo models, our findings reveal that Nrf2/HO-1 modulation significantly reduces neuroinflammation and oxidative damage, offering a potential therapeutic strategy for managing hepatic encephalopathy. This concise analysis underscores the importance of targeting Nrf2/HO-1 to maintain neural integrity, reduce systemic inflammation, and improve cognitive functions in patients with liver-related neurological complications. |
| Publish Date |
2025-08-26 10:18 |
| Citation |
Zhang YM, Zhang ZG. Modulating nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 in liver-brain axis disorders. World J Psychiatry 2025; 15(9): 108382 |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i9/108382.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i9.108382 |
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